Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Tumor 247 articles


Does Expression of Glucose Transporter Protein-1 Relate to Prognosis and Angiogenesis in Osteosarcoma?

Tadahiko Kubo MD PhD, Shoji Shimose MD PhD, Jun Fujimori MD PhD, Taisuke Furuta MD, Koji Arihiro MD PhD, Mitsuo Ochi MD PhD

The survival of patients who present with nonmetastatic extremity osteosarcoma has dramatically improved, but there are some patients who do not respond to chemotherapy. The ability to identify patients with a poorer prognosis might allow us to target different therapy for these patients. Glucose transporter protein-1 (Glut-1), one of the key factors in glucose metabolism, has been reported to be an independent prognostic factor in various tumors. However, little is known about the role of the Glut-1 pathway in osteosarcoma.

Antirotation Pins Improve Stability of the Compress Limb Salvage Implant: A Biomechanical Study

Raffi S. Avedian MD, Timothy Chen MD, Derek Lindsey MS, Ariel Palanca MD, David Mohler MD

Limb salvage implants that rely on compliant compression osseointegration to achieve bone fixation may achieve longer survivorship rates compared with traditional cemented or press-fit stemmed implants; however, failures resulting from rotational instability have been reported. The effect of using antirotation pins on the rotational stability of the fixation has not been well studied.

What Is the Effect of Advanced Age and Comorbidity on Postoperative Morbidity and Mortality After Musculoskeletal Tumor Surgery?

Koichi Ogura MD, Hideo Yasunaga MD, PhD, Hiromasa Horiguchi PhD, Kiyohide Fushimi MD, PhD, Hirotaka Kawano MD, PhD

Although the elderly population is increasing rapidly, little information is available regarding how the risk of postoperative mortality and morbidity increases when combined with age and comorbidity burden in patients undergoing musculoskeletal tumor surgery.

Thigh Pain in an 18-year-old Man

Frank Traub MD, PhD, Marilyn Heng MD, Brendan C. Dickson MD, MSc, Peter C. Ferguson MD, MSc

MicroRNA Regulates Vascular Endothelial Growth Factor Expression in Chondrosarcoma Cells

Xiaojuan Sun MD, PhD, Lei Wei MD, PhD, Qian Chen PhD, Richard M. Terek MD

Systemic treatments to prevent or treat chondrosarcoma metastasis are lacking and targeted therapy has yet to be developed. Hypoxia develops in tumors as they grow and hypoxia-related alterations in gene expression underlie some of the traits of cancer. One critical trait is the ability to induce sustained angiogenesis, which is usually related to expression of vascular endothelial growth factor (VEGF). A potential hypoxia-related mechanism resulting in altered gene expression involves microRNA. Little is known about microRNA expression in chondrosarcoma and its potential role in regulation of VEGF expression.

Is Claviculo Pro Humeri of Value for Limb Salvage of Pediatric Proximal Humerus Sarcomas?

George T. Calvert MD, Jennifer Wright MD, Jayant Agarwal MD, Kevin B. Jones MD, R. Lor Randall MD

There are several options for proximal humerus reconstruction in young children after resection of a malignant tumor and no one technique has been definitively shown to be superior to others, leaving the decision to surgeon and patient choice. Claviculo pro humeri (CPH) is a biologic reconstruction of the proximal humerus using the patient’s ipsilateral clavicle as a rotational osseous flap. CPH represents a potential option for this complicated clinical problem in very young children, but little is known about it because the indications for its use are so uncommon.

Is Curettage and High-speed Burring Sufficient Treatment for Aneurysmal Bone Cysts?

Edward H. M. Wang MD, MSc, Michael L. Marfori MD, Ma Victoria T. Serrano PTRP, Donnel Alexis Rubio MD

To decrease the recurrence rate after intralesional curettage for aneurysmal bone cysts, different adjuvant treatments have been recommended. Liquid nitrogen spray and argon beam coagulation have provided the lowest recurrence rates, but unlike the high-speed burr, these adjuvants are not always available in operating rooms.

What Sports Activity Levels Are Achieved in Patients With Modular Tumor Endoprostheses of Osteosarcoma About the Knee?

Nikolaus W. Lang MD, Gerhard M. Hobusch MD, Philipp T. Funovics MD, Reinhard Windhager MD, Jochen G. Hofstaetter MD

Advances in multimodal treatment have improved survival of patients with nonmetastatic osteosarcoma. At the same time, implant design has improved the outcomes of limb salvage with modular endoprostheses. However, little is known about sports activity in long-term survivors with osteosarcoma.

Do Long Term Survivors of Ewing Family of Tumors Experience Low Bone Mineral Density and Increased Fracture Risk?

Gerhard M. Hobusch MD, Iris Noebauer-Huhmann MD, PhD, Christoph Krall PhD, Gerold Holzer MD, PhD

Multimodal treatment regimens for Ewing’s sarcoma have led to survival rates approaching 70% of patients with no metastases at diagnosis. However, these treatments have long-term side effects. Low bone mineral density (BMD) and risk of fractures can occur owing in part to chemotherapy and limited mobility from local control of the primary tumor.

What Are the Results Using the Modified Trapdoor Procedure to Treat Chondroblastoma of the Femoral Head?

Hairong Xu MD, Xiaohui Niu MD, Yuan Li MD, Odion T. Binitie MD, G. Douglas Letson MD, David Cheong MD

Treatment of chondroblastoma in the femoral head is challenging owing to the particular location and its aggressive nature. There is little published information to guide the surgeon regarding the appropriate approach to treating a chondroblastoma in this location. We developed a modified trapdoor procedure to address this issue. The primary modification is that the window surface of the femoral head is covered by the ligamentum teres rather than cartilage as in the traditional procedure.