Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Tumor 242 articles


Antibacterial and Biocompatible Titanium-Copper Oxide Coating May Be a Potential Strategy to Reduce Periprosthetic Infection: An In Vitro Study

German A. Norambuena MD, Robin Patel MD, Melissa Karau MT, Cody C. Wyles BS, Paul J. Jannetto PhD, Kevin E. Bennet BSChE, MBA, Arlen D. Hanssen MD, Rafael J. Sierra MD

Periprosthetic infections are devastating for patients and more efficacious preventive strategies are needed. Surface-modified implants using antibacterial coatings represent an option to cope with this problem; however, manufacturing limitations and cytotoxicity have curbed clinical translation. Among metals with antibacterial properties, copper has shown superior in vitro antibacterial performance while maintaining an acceptable cytotoxicity profile. A thin film containing copper could prevent early biofilm formation to limit periprosthetic infections. This pilot study presents the in vitro antibacterial effect, cytotoxicity, and copper ion elution pattern of a thin film of titanium-copper oxide (TiCuO).

How Much Clinical and Functional Impairment do Children Treated With Knee Rotationplasty Experience in Adulthood?

Maria Grazia Benedetti MD, Yusuke Okita PT, PhD, Elena Recubini MD, Elisabetta Mariani MD, Alberto Leardini PhD, Marco Manfrini MD

Rotationplasty may be indicated for some children with osteosarcoma in the distal femur or proximal tibia; in properly selected patients, it may offer functional advantages over transfemoral amputation and more durable results than a prosthesis. The clinical and functional outcomes reported for this procedure generally have been limited to studies with a mean followup of approximately 8 years in terms of Musculoskeletal Tumor Society Score (MSTS), physical examination, and gait analysis. However, the effects of residual thigh-shank length on gait have not been explored to our knowledge.

What Are the Long-term Results of MUTARS® Modular Endoprostheses for Reconstruction of Tumor Resection of the Distal Femur and Proximal Tibia?

Michaël P. A. Bus MSc, Michiel A. J. Sande MD, PhD, Marta Fiocco PhD, Gerard R. Schaap MD, PhD, Jos A. M. Bramer MD, PhD, P. D. Sander Dijkstra MD, PhD

Modular endoprostheses are commonly used to reconstruct defects of the distal femur and proximal tibia after bone tumor resection. Because limb salvage surgery for bone sarcomas is relatively new, becoming more frequently used since the 1980s, studies focusing on the long-term results of such prostheses in treatment of primary tumors are scarce.

Outcomes of a Modular Intercalary Endoprosthesis as Treatment for Segmental Defects of the Femur, Tibia, and Humerus

Joseph Benevenia MD, Rainer Kirchner MD, Francis Patterson MD, Kathleen Beebe MD, Dieter C. Wirtz MD, Steven Rivero MD, Mark Palma MS, Max J. Friedrich MD

Resection of diaphyseal bone tumors for local tumor control and stabilization often results in an intercalary skeletal defect and presents a reconstructive challenge for orthopaedic surgeons. Although many options for reconstruction have been described, relatively few studies report on the functional outcomes and complications of patients treated with modular intercalary endoprostheses.

Sacral Insufficiency Fractures are Common After High-dose Radiation for Sacral Chordomas Treated With or Without Surgery

Polina Osler MS, Miriam A. Bredella MD, Kathryn A. Hess BS, Stein J. Janssen MD, Christine J. Park BS, Yen Lin Chen MD, Thomas F. DeLaney MD, Francis J. Hornicek MD, PhD, Joseph H. Schwab MD, MS

Surgery with high-dose radiation and high-dose radiation alone for sacral chordomas have shown promising local control rates. However, we have noted frequent sacral insufficiency fractures and perceived this rate to be higher than previously reported.

Revision Distal Femoral Arthroplasty With the Compress® Prosthesis Has a Low Rate of Mechanical Failure at 10 Years

Melissa N. Zimel MD, German L. Farfalli MD, Alexandra M. Zindman BA, Elyn R. Riedel MA, Carol D. Morris MD, Patrick J. Boland MD, John H. Healey MD

Patients with failed distal femoral megaprostheses often have bone loss that limits reconstructive options and contributes to the high failure rate of revision surgery. The CompressCompliant Pre-stress (CPS) implant can reconstruct the femur even when there is little remaining bone. It differs from traditional stemmed prostheses because it requires only 4 to 8 cm of residual bone for fixation. Given the poor long-term results of stemmed revision constructs, we sought to determine the failure rate and functional outcomes of the CPS implant in revision surgery.

Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?

Zhengfu Fan MD, PhD, Shreyaskumar Patel MD, Valerae O. Lewis MD, B. Ashleigh Guadagnolo MD, Patrick P. Lin MD

Extraosseous osteosarcoma is rare, and the most appropriate therapy is unclear because there are few studies regarding its treatment. The effectiveness of radiation and chemotherapy remains uncertain owing to conflicting results in previous reports.

A 26-year-old Woman With Bilateral Leg Pain and Pruritus

S. M. Morell MD, Jerad M. Gardner MD, L. J. Suva PhD, C. O. Montgomery MD

CT-based Structural Rigidity Analysis Is More Accurate Than Mirels Scoring for Fracture Prediction in Metastatic Femoral Lesions

Timothy A. Damron MD, Ara Nazarian PhD, Vahid Entezari MD, Carlos Brown MD, William Grant EdD, Nathan Calderon MSc, David Zurakowski PhD, Richard M. Terek MD, Megan E. Anderson MD, Edward Y. Cheng MD, Albert J. Aboulafia MD, Mark C. Gebhardt MD, Brian D. Snyder MD, PhD

Controversy continues regarding the appropriate assessment of fracture risk in long bone lesions affected by disseminated malignancy.

Does Microwave Ablation of the Tumor Edge Allow for Joint-sparing Surgery in Patients With Osteosarcoma of the Proximal Tibia?

Jing Li MD, PhD, Zheng Guo MD, PhD, Zhen Wang MD, Hongbin Fan MD, Jun Fu MD

Joint-sparing surgery of a patient’s native joint for osteosarcoma likely affords better function and comparable survival. However, it sometimes is challenging to resect a juxtaarticular osteosarcoma in a way that preserves the affected epiphysis because wide margins are necessary to minimize the risk of local recurrence. If there was a method to resect a tumor close to the joint and treat a potentially positive margin to prevent recurrence, it might allow salvage of a joint that otherwise might be lost.