Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Tumor 242 articles


Aseptic Loosening Rates in Distal Femoral Endoprostheses: Does Stem Size Matter?

Patrick F. Bergin MD, Jenna B. Noveau BS, James S. Jelinek MD, Robert M. Henshaw MD

Long-term survival of distal femoral endoprosthetic replacements is largely affected by aseptic loosening. It is unclear whether and to what degree surgical technique and component selection influence the risk of loosening.

Epithelioid Hemangioma of Bone and Soft Tissue: A Reappraisal of a Controversial Entity

Costantino Errani MD, Lei Zhang MD, David M. Panicek MD, John H. Healey MD, Cristina R. Antonescu MD

The controversy surrounding diagnosis of an epithelioid hemangioma (EH), particularly when arising in skeletal locations, stems not only from its overlapping features with other malignant vascular neoplasms, but also from its somewhat aggressive clinical characteristics, including multifocal presentation and occasional lymph node involvement. Specifically, the distinction from epithelioid hemangioendothelioma (EHE) has been controversial. The recurrent t(1;3)(p36;q25) chromosomal translocation, resulting in WWTR1-CAMTA1 fusion, recently identified in EHE of various anatomic sites, but not in EH or other epithelioid vascular neoplasms, suggests distinct pathogeneses.

Orthopaedic Case of the Month: A 50-year-old Woman with Persistent Knee Pain

Brian E. Walczak DO, MPT, Dorothy M. Halperin MD, Rabei W. Bdeir MD, Ronald B. Irwin MD

Sixty Percent 10-year Survival of Patients With Chondrosarcoma After Local Recurrence

Patrick P. Lin MD, Mohammed D. Alfawareh MD, Akihiko Takeuchi MD, PhD, Bryan S. Moon MD, Valerae O. Lewis MD

Chondrosarcoma is treated primarily by surgery. The prognosis of patients after local recurrence is not well defined. Both the survival of patients and the risk of further local relapse after surgical treatment of local recurrence have yet to be established.

Endoprosthetic Treatment is More Durable for Pathologic Proximal Femur Fractures

Matthew Steensma MD, Patrick J. Boland MD, Carol D. Morris MD, Edward Athanasian MD, John H. Healey MD

Pathologic proximal femur fractures result in substantial morbidity for patients with skeletal metastases. Surgical treatment is widely regarded as effective; however, failure rates associated with the most commonly used operative treatments are not well defined.

Endoprostheses Last Longer Than Intramedullary Devices in Proximal Femur Metastases

Norah Harvey MD, Elke R. Ahlmann MD, Daniel C. Allison MD, MBA, Lingjun Wang PA, Lawrence R. Menendez MD, FACS

The proximal femur is the most common site of surgery for bone metastases, and stabilization may be achieved through intramedullary fixation (IMN) or endoprosthetic reconstruction (EPR). Intramedullary devices are less expensive, less invasive, and may yield improved function over endoprostheses. However, it is unclear which, if either, has any advantages.

What Are Risk Factors for Local Recurrence of Deep High-grade Soft-tissue Sarcomas?

Chigusa Sawamura MD, MPH, Seiichi Matsumoto MD, PhD, Takashi Shimoji MD, PhD, Taisuke Tanizawa MD, Keisuke Ae MD, PhD

Patients with local recurrence of soft-tissue sarcomas have a poor overall survival. High-grade, soft-tissue sarcomas in deep locations may have a poorer prognosis regarding local recurrence than low-grade sarcomas or those located superficially. Although previous reports evaluated tumors at various depths, it is unclear what factors influence recurrence of deep, high-grade sarcomas.

Orthopaedic Case of the Month: Painful Lower-leg Mass in a 76-year-old Man

Prasad J. Sawardeker MD, MS, Check C. Kam MD, J. David Pitcher MD, H. Thomas Temple MD

Survival, Local Recurrence, and Function After Pelvic Limb Salvage at 23 to 38 Years of Followup

Courtney E. Sherman MD, Mary I. O’Connor MD, Franklin H. Sim MD

Malignant pelvic tumors frequently pose challenges to surgeons owing to complex pelvic anatomy and local extension. External hemipelvectomy frequently allows adequate margins but is associated with substantial morbidity and reduced function. Limb salvage is an alternative approach when adequate margins can be achieved, but long-term function and survival are unclear.

Similar Local Control between Phenol- and Ethanol-treated Giant Cell Tumors of Bone

Wei-Hsin Lin MD, Tsung-Yu Lan MD, Chih-Yu Chen MD, Karl Wu MD, Rong-Sen Yang MD

Giant cell tumors (GCTs) of bone often are treated with curettage, adjuvant therapy, and cementation. Phenol is a commonly used adjuvant associated with local control rates ranging from 9% to 25%. However, it is corrosive to the eyes, skin, and respiratory tract. Ethanol is readily available and does not cause chemical burns on contact, but it is unclear whether ethanol can achieve similar local control rates as phenol for treating GCTs.