Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Tumor 242 articles


Giant Cell Tumor of Bone: Are We Stratifying Results Appropriately?

Thomas J. Kremen MD, Nicholas M. Bernthal MD, Mark A. Eckardt BS, Jeffrey J. Eckardt MD

There is no consensus as to which surgical approach to the treatment of giant cell tumor of bone is most appropriate or which patients are at a higher risk for recurrence or metastasis.

Extremity Soft Tissue Sarcoma Resections: How Wide Do You Need to Be?

David M. King MD, Donald A. Hackbarth MD, Andrew Kirkpatrick BS

Sarcomas require a wide margin of resection including a cuff of normal tissue to minimize the risk of local recurrence. The amount of tissue that constitutes a wide margin is unclear in the literature.

Does Adjunctive Chemotherapy Reduce Remission Rates Compared to Cortisone Alone in Unifocal or Multifocal Histiocytosis of Bone?

André Mathias Baptista MD, PhD, André Ferrari França Camargo MD, Olavo Pires Camargo MD, PhD, Vicente Odone Filho MD, PhD, Alejandro Enzo Cassone MD, PhD

Langerhans cell histiocytosis (LCH) is a rare disorder that can affect almost any organ, including bone. Treatment options include local corticosteroid infiltration in isolated bone lesions and oral corticosteroids and chemotherapy in multifocal bone lesions. Several studies show local corticosteroid injection in unifocal bone lesions heal in more than 75% of patients with minimal side effects. Therefore, it is unclear whether chemotherapy adds materially to the healing rate.

Aseptic Failure: How Does the Compress® Implant Compare to Cemented Stems?

Andrew C. Pedtke MD, Rosanna L. Wustrack MD, Andrew S. Fang MD, Robert J. Grimer FRCS, Richard J. O’Donnell MD

Failure of endoprosthetic reconstruction with conventional stems due to aseptic loosening remains a challenge for maintenance of limb integrity and function. The Compressimplant (Biomet Inc, Warsaw, IN, USA) attempts to avoid aseptic failure by means of a unique technologic innovation. Though the existing literature suggests survivorship of Compressand stemmed implants is similar in the short term, studies are limited by population size and followup duration.

Local Recurrence has only a Small Effect on Survival in High-risk Extremity Osteosarcoma

Chang-Bae Kong MD, Won Seok Song MD, Wan Hyeong Cho MD, Jung Moon Oh MD, Dae-Geun Jeon MD

Tumor enlargement after chemotherapy is considered one of the high-risk factors for local recurrence and survival in osteosarcoma. We hypothesized patients with this risk factor will have similar survival regardless of the development of local recurrence.

Surgical Technique: Methods for Removing a Compress® Compliant Prestress Implant

Geoffrey D. Abrams MD, Varun K. Gajendran MD, David G. Mohler MD, Raffi S. Avedian MD

The Compress® device uses a unique design using compressive forces to achieve bone ingrowth on the prosthesis. Because of its design, removal of this device may require special techniques to preserve host bone.

Surgical Technique: Porous Tantalum Reconstruction for Destructive Nonprimary Periacetabular Tumors

Fazel A. Khan MD, Peter S. Rose MD, Michiro Yanagisawa MD, David G. Lewallen MD, Franklin H. Sim MD

Large bone loss and frequently irradiated existing bone make reconstructing metastatic and other nonprimary periacetabular tumors challenging. Although existing methods are initially successful, they may fail with time. Given the low failure rates of porous tantalum acetabular implants in other conditions with large bone loss or irradiated bone, we developed a technique to use these implants in these neoplastic cases where others might fail.

Early Complications of High-dose-rate Brachytherapy in Soft Tissue Sarcoma: A Comparison With Traditional External-beam Radiotherapy

Cynthia L. Emory MD, Corey O. Montgomery MD, Benjamin K. Potter MD, Martin E. Keisch MD, Sheila A. Conway MD

Radiotherapy and surgery are routinely utilized to treat extremity soft tissue sarcoma. Multiple radiation modalities have been described, each with advantages and disadvantages, without one modality demonstrating clear superiority over the others.

Navigation-assisted Surgery for Bone and Soft Tissue Tumors With Bony Extension

Makoto Ieguchi MD, Manabu Hoshi MD, PhD, Jun Takada MD, Noriaki Hidaka MD, PhD, Hiroaki Nakamura MD, PhD

The navigation system was introduced to orthopaedic surgery in the 1990s. More recently, CT-based navigation systems have been used more commonly in spine and joint replacement surgery because of their precision.