Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Tumor 239 articles


Does Adjunctive Chemotherapy Reduce Remission Rates Compared to Cortisone Alone in Unifocal or Multifocal Histiocytosis of Bone?

André Mathias Baptista MD, PhD, André Ferrari França Camargo MD, Olavo Pires Camargo MD, PhD, Vicente Odone Filho MD, PhD, Alejandro Enzo Cassone MD, PhD

Langerhans cell histiocytosis (LCH) is a rare disorder that can affect almost any organ, including bone. Treatment options include local corticosteroid infiltration in isolated bone lesions and oral corticosteroids and chemotherapy in multifocal bone lesions. Several studies show local corticosteroid injection in unifocal bone lesions heal in more than 75% of patients with minimal side effects. Therefore, it is unclear whether chemotherapy adds materially to the healing rate.

Aseptic Failure: How Does the Compress® Implant Compare to Cemented Stems?

Andrew C. Pedtke MD, Rosanna L. Wustrack MD, Andrew S. Fang MD, Robert J. Grimer FRCS, Richard J. O’Donnell MD

Failure of endoprosthetic reconstruction with conventional stems due to aseptic loosening remains a challenge for maintenance of limb integrity and function. The Compressimplant (Biomet Inc, Warsaw, IN, USA) attempts to avoid aseptic failure by means of a unique technologic innovation. Though the existing literature suggests survivorship of Compressand stemmed implants is similar in the short term, studies are limited by population size and followup duration.

Local Recurrence has only a Small Effect on Survival in High-risk Extremity Osteosarcoma

Chang-Bae Kong MD, Won Seok Song MD, Wan Hyeong Cho MD, Jung Moon Oh MD, Dae-Geun Jeon MD

Tumor enlargement after chemotherapy is considered one of the high-risk factors for local recurrence and survival in osteosarcoma. We hypothesized patients with this risk factor will have similar survival regardless of the development of local recurrence.

Surgical Technique: Methods for Removing a Compress® Compliant Prestress Implant

Geoffrey D. Abrams MD, Varun K. Gajendran MD, David G. Mohler MD, Raffi S. Avedian MD

The Compress® device uses a unique design using compressive forces to achieve bone ingrowth on the prosthesis. Because of its design, removal of this device may require special techniques to preserve host bone.

Surgical Technique: Porous Tantalum Reconstruction for Destructive Nonprimary Periacetabular Tumors

Fazel A. Khan MD, Peter S. Rose MD, Michiro Yanagisawa MD, David G. Lewallen MD, Franklin H. Sim MD

Large bone loss and frequently irradiated existing bone make reconstructing metastatic and other nonprimary periacetabular tumors challenging. Although existing methods are initially successful, they may fail with time. Given the low failure rates of porous tantalum acetabular implants in other conditions with large bone loss or irradiated bone, we developed a technique to use these implants in these neoplastic cases where others might fail.

Early Complications of High-dose-rate Brachytherapy in Soft Tissue Sarcoma: A Comparison With Traditional External-beam Radiotherapy

Cynthia L. Emory MD, Corey O. Montgomery MD, Benjamin K. Potter MD, Martin E. Keisch MD, Sheila A. Conway MD

Radiotherapy and surgery are routinely utilized to treat extremity soft tissue sarcoma. Multiple radiation modalities have been described, each with advantages and disadvantages, without one modality demonstrating clear superiority over the others.

Navigation-assisted Surgery for Bone and Soft Tissue Tumors With Bony Extension

Makoto Ieguchi MD, Manabu Hoshi MD, PhD, Jun Takada MD, Noriaki Hidaka MD, PhD, Hiroaki Nakamura MD, PhD

The navigation system was introduced to orthopaedic surgery in the 1990s. More recently, CT-based navigation systems have been used more commonly in spine and joint replacement surgery because of their precision.

Aseptic Loosening Rates in Distal Femoral Endoprostheses: Does Stem Size Matter?

Patrick F. Bergin MD, Jenna B. Noveau BS, James S. Jelinek MD, Robert M. Henshaw MD

Long-term survival of distal femoral endoprosthetic replacements is largely affected by aseptic loosening. It is unclear whether and to what degree surgical technique and component selection influence the risk of loosening.

Epithelioid Hemangioma of Bone and Soft Tissue: A Reappraisal of a Controversial Entity

Costantino Errani MD, Lei Zhang MD, David M. Panicek MD, John H. Healey MD, Cristina R. Antonescu MD

The controversy surrounding diagnosis of an epithelioid hemangioma (EH), particularly when arising in skeletal locations, stems not only from its overlapping features with other malignant vascular neoplasms, but also from its somewhat aggressive clinical characteristics, including multifocal presentation and occasional lymph node involvement. Specifically, the distinction from epithelioid hemangioendothelioma (EHE) has been controversial. The recurrent t(1;3)(p36;q25) chromosomal translocation, resulting in WWTR1-CAMTA1 fusion, recently identified in EHE of various anatomic sites, but not in EH or other epithelioid vascular neoplasms, suggests distinct pathogeneses.

Orthopaedic Case of the Month: A 50-year-old Woman with Persistent Knee Pain

Brian E. Walczak DO, MPT, Dorothy M. Halperin MD, Rabei W. Bdeir MD, Ronald B. Irwin MD