Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Tumor 239 articles

Articles

Adverse Reactions of Artificial Bone Graft Substitutes: Lessons Learned From Using Tricalcium Phosphate geneX®

Joerg Friesenbichler MD, Werner Maurer-Ertl MD, Patrick Sadoghi MD, Ulrike Pirker-Fruehauf MD, Koppany Bodo MD, Andreas Leithner MD

Artificial bone graft substitutes are widely used to fill bony defects after curettage of benign tumors. We sought to evaluate the efficacy of one such bone graft substitute, geneX, which contains tricalcium phosphate and calcium sulphate; however, during the course of this study we observed a high number of complications.

Infection After Surgical Resection for Pelvic Bone Tumors: An Analysis of 270 Patients From One Institution

Andrea Angelini MD, Gabriele Drago MD, Giulia Trovarelli MD, Teresa Calabrò MD, Pietro Ruggieri MD, PhD

Surgical treatment of pelvic tumors with or without acetabular involvement is challenging. Primary goals of surgery include local control and maintenance of good quality of life, but the procedures are marked by significant perioperative morbidity and complications.

Validation of the Brazilian Version of the Musculoskeletal Tumor Society Rating Scale for Lower Extremity Bone Sarcoma

Daniel Cesar Seguel Rebolledo MD, João Ricardo Nickenig Vissoci MD, Ricardo Pietrobon MD, PhD, Olavo Pires Camargo MD, PhD, Andre Mathias Baptista MD, PhD

The Musculoskeletal Tumor Society (MSTS) rating scale is an English-language instrument used worldwide to assess functional evaluation of patients with musculoskeletal cancer. Despite its use in several studies in English-speaking countries, its validity for assessing patients in other languages is unknown. The translation and validation of widely used scales can facilitate the comparison across international patient samples.

The Phosphaturic Mesenchymal Tumor: Why is Definitive Diagnosis and Curative Surgery Often Delayed?

Cameron K. Ledford MD, Nicole A. Zelenski BS, Diana M. Cardona MD, Brian E. Brigman MD, PhD, William C. Eward DVM, MD

Tumor-induced osteomalacia is a paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. Phosphaturic mesenchymal tumors represent a rare etiology of tumor-induced osteomalacia. Nonspecific symptoms of fatigue, bone pain, and musculoskeletal weakness make the diagnosis elusive and lead to a delay in surgical treatment.

Image Guided Core Needle Biopsy of Musculoskeletal Lesions: Are Nondiagnostic Results Clinically Useful?

Manjiri M. Didolkar MD, MS, Megan E. Anderson MD, Mary G. Hochman MD, MBA, Julia G. Rissmiller MD, Jeffrey D. Goldsmith MD, Mark G. Gebhardt MD, Jim S. Wu MD

The clinical utility of nondiagnostic core needle biopsies is not fully understood. Understanding the clinical and radiologic factors associated with nondiagnostic core needle biopsies may help determine the utility of these nondiagnostic biopsies and guide clinical decision making.

Conditional Survival Is Greater Than Overall Survival at Diagnosis in Patients With Osteosarcoma and Ewing’s Sarcoma

Benjamin J. Miller MD, MS, Charles F. Lynch MD, MS, PhD, Joseph A. Buckwalter MD, MS

Conditional survival is a measure of the risk of mortality given that a patient has survived a defined period of time. These estimates are clinically helpful, but have not been reported previously for osteosarcoma or Ewing’s sarcoma.

Knee Pain in a 9-year-old Girl

Eric R. Henderson MD, Rebecca A. Pohlmann MD, Lisa A. Teot MD, Mark C. Gebhardt MD

Silver Negative Pressure Dressing With Vacuum-assisted Closure of Massive Pelvic and Extremity Wounds

Herrick J. Siegel MD, Diego F. Herrera MD, Jason Gay CRNFA

Massive soft tissue loss involving the pelvis and extremities from trauma, infections, and tumors remains a challenging and debilitating problem. Although vacuum-assisted closure (VAC) technology is effective in the management of soft tissue loss, the adjunct of a silver dressing in the setting of massive wounds has not been as well tested.

Complications of Cemented Long-stem Hip Arthroplasty in Metastatic Bone Disease Revisited

Shawn L. Price MD, M. Aabid Farukhi BA, Kevin B. Jones MD, Stephen K. Aoki MD, R. Lor Randall MD, FACS

The literature suggests that a cemented long-stem femoral arthroplasty is associated with increased intraoperative and perioperative risks. Embolic events may precipitate cardiopulmonary complications and even death; by contrast, others have reported that the use of a cemented long-stem femoral arthroplasty in patients with metastatic bone disease is a safe procedure.

Chick Embryo Extract Demethylates Tumor Suppressor Genes in Osteosarcoma Cells

Xiaodong Mu PhD, Bolat Sultankulov BS, Riddhima Agarwal, Adel Mahjoub, Trevor Schott BS, Nicholas Greco MD, Johnny Huard PhD, Kurt Weiss MD

Epigenetics is the study of changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence. It is widely accepted that cancer has genetic and epigenetic origins. The idea of epigenetic reprogramming of cancer cells by an embryonic microenvironment possesses potential interest from the prospect of both basic science and potential therapeutic strategies. Chick embryo extract (CEE) has been used for the successful expansion of many specific stem cells and has demonstrated the ability to facilitate DNA demethylation.