Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Tumor 247 articles


Operative Management of Metastatic Melanoma in Bone May Require En Bloc Resection of Disease

Jeffrey E. Krygier MD, Valerae O. Lewis MD, Christopher P. Cannon MD, Robert L. Satcher MD, Bryan S. Moon MD, Patrick P. Lin MD

Bone metastasis is a poor prognostic indicator in melanoma. Some authors have advocated only palliative treatment for patients with osseous disease.

What Are the Factors That Affect Survival and Relapse After Local Recurrence of Osteosarcoma?

Akihiko Takeuchi MD, PhD, Valerae O. Lewis MD, Robert L. Satcher MD, Bryan S. Moon MD, Patrick P. Lin MD

Despite improvements in treatment of primary osteosarcoma, treatment of patients who have local recurrence is not well defined.

What Was the Survival of Megaprostheses in Lower Limb Reconstructions After Tumor Resections?

Rodolfo Capanna MD, Guido Scoccianti MD, Filippo Frenos MD, Antonio Vilardi MD, Giovanni Beltrami MD, Domenico Andrea Campanacci MD

Prosthetic replacement is the most commonly used option for reconstruction of osteoarticular bone loss resulting from bone neoplasm resection or prosthetic failure. Starting in late 2001, we began exclusively using a single system for large-segment osteoarticular reconstruction after tumor resection; to our knowledge, there are no published series from one center evaluating the use of this implant.

Embolization of Hypervascular Bone Metastases Reduces Intraoperative Blood Loss: A Case-control Study

Theresa J. C. Pazionis MD, MA, Ioannis D. Papanastassiou MD, PhD, Majid Maybody MD, John H. Healey MD

Small case series suggest that preoperative transcatheter arterial embolization minimizes bleeding and facilitates surgery for hypervascular metastatic bone tumors. However, control groups would make our confidence in clinical recommendations stronger, but small patient numbers make prospective trials difficult to conduct on this topic.

What Are the 5-year Survivorship Outcomes of Compressive Endoprosthetic Osseointegration Fixation of the Femur?

Michael J. Monument MD, Nicholas M. Bernthal MD, Austin J. Bowles MS, Kevin B. Jones MD, R. Lor Randall MD

Aseptic complications such as stress shielding leading to bone loss are major problems associated with revision of cemented and uncemented long-stem tumor endoprostheses. Endoprosthetic reconstruction using compressive osseointegration fixation is a relatively new limb salvage technology designed to enhance osseointegration, prevent stress shielding, and provide fixation for short end-segments.

Obesity Does Not Affect Survival Outcomes in Extremity Soft Tissue Sarcoma

Vignesh K. Alamanda BS, David C. Moore MD, Yanna Song MS, Herbert S. Schwartz MD, Ginger E. Holt MD

Obesity is a growing epidemic and has been associated with an increased frequency of complications after various surgical procedures. Studies also have shown adipose tissue to promote a microenvironment favorable for tumor growth. Additionally, the relationship between obesity and prognosis of soft tissue sarcomas has yet to be evaluated.

Aggressive Tibial Lesion in a 70-year-old Man

Jacob M. Kirsch MD, Andrew E. Rosenberg MD, Brian J. O’Hara MD, John A. Abraham MD

Does Competing Risk Analysis Give Useful Information About Endoprosthetic Survival in Extremity Osteosarcoma?

Reinhard Schuh MD, Alexandra Kaider MSc, Reinhard Windhager MD, Philipp T. Funovics MD

Conventional survival analysis for endoprosthetic complications does not consider competing events adequately. Patients who die of their disease are no longer at risk for complications; therefore, death as a competing event may alter survivorship estimates in the orthopaedic-oncological setting.

Survival of Modern Knee Tumor Megaprostheses: Failures, Functional Results, and a Comparative Statistical Analysis

Elisa Pala MD, Giulia Trovarelli MD, Teresa Calabrò MD, Andrea Angelini MD, Caterina N. Abati MD, Pietro Ruggieri MD, PhD

Modular megaprostheses are now the most common method of reconstruction after segmental resection of the long bones in the lower extremities. Previous studies reported variable outcome and failure rates after knee megaprosthetic reconstructions.

Should Fractures in Massive Intercalary Bone Allografts of the Lower Limb Be Treated With ORIF or With a New Allograft?

Luis A. Aponte-Tinao MD, Miguel A. Ayerza MD, D. Luis Muscolo MD, Germán L. Farfalli MD

Massive bone allografts have been used for limb salvage of bone tumor resections as an alternative to endoprostheses, although they have different outcomes and risks. There is no general consensus about when to use these alternatives, but when it is possible to save the native joints after the resection of a long bone tumor, intercalary allografts offer some advantages despite complications, such as fracture. The management and outcomes of this complication deserve more study.