Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Knee 450 articles


Cartilage Matrix Formation by Bovine Mesenchymal Stem Cells in Three-dimensional Culture Is Age-dependent

Isaac E. Erickson BS, Steven C. Veen, Swarnali Sengupta, Sydney R. Kestle, Robert L. Mauck PhD

Cartilage degeneration is common in the aged, and aged chondrocytes are inferior to juvenile chondrocytes in producing cartilage-specific extracellular matrix. Mesenchymal stem cells (MSCs) are an alternative cell type that can differentiate toward the chondrocyte phenotype. Aging may influence MSC chondrogenesis but remains less well studied, particularly in the bovine system.

Can Wedge Osteotomy Correct Depression of the Lateral Tibial Plateau Mimicking Posterolateral Rotatory Knee Instability?

Miguel A. Ayerza MD, Federico Suarez MD, Matias Costa-Paz MD, D. Luis Muscolo MD

The literature suggests rotatory knee instability (pseudolaxity) can be associated with depressions of the lateral tibial plateau in patients despite an intact arcuate ligament complex. Correcting this bone deformity by an open-wedge osteotomy of the lateral tibia plateau, elevating the depressed bone may restore knee stability.

Degradation Improves Tissue Formation in (Un)Loaded Chondrocyte-laden Hydrogels

Justine J. Roberts BS, Garret D. Nicodemus PhD, Eric C. Greenwald MS, Stephanie J. Bryant PhD

Photopolymerizable poly(ethylene glycol) (PEG) hydrogels offer a platform to deliver cells in vivo and support three-dimensional cell culture but should be designed to degrade in sync with neotissue development and endure the physiologic environment.

Does High Tibial Osteotomy Affect the Success or Survival of a Total Knee Replacement?

John B. Meding MD, Jennifer T. Wing, Merrill A. Ritter MD

Whether a previous high tibial osteotomy (HTO) influences the long-term function or survival of a total knee arthroplasty (TKA) is controversial.

2010 Mid-America Orthopaedic Association Physician in Training Award: Predictors of Early Adverse Outcomes after Knee and Hip Arthroplasty in Geriatric Patients

Carlos A. Higuera MD, Karim Elsharkawy MD, MRCS, Alison K. Klika MS, Matthew Brocone BS, Wael K. Barsoum MD

Geriatric patients experience more adverse events owing to early complications after TKA or THA related to preexisting comorbidities. However, associations between patient and surgery variables, including age, BMI, and comorbidities with complications are unclear. Knowing these relationships is necessary for developing risk stratification, defining contraindications, and predicting complications and adverse outcomes.

Is Noncontact ACL Injury Associated with the Posterior Tibial and Meniscal Slope?

R. Hudek MD, B. Fuchs MD, PhD, F. Regenfelder MD, P. P. Koch MD

The risk of noncontact ACL injury reportedly is increased in patients with a greater posterior tibial slope (PTS), but clinical data are inconsistent. It is unclear whether the medial and lateral PTSs have a different impact on this connection. It also is unknown whether the meniscal slope (MS) is associated with ACL injury.

Does Tranexamic Acid Save Blood in Minimally Invasive Total Knee Arthroplasty?

Po-Chun Lin MD, Chi-Hsiang Hsu MD, Wun-Schen Chen MD, Jun-Wen Wang MD

Tranexamic acid (TEA) reportedly reduces perioperative blood loss in TKA. However, whether it does so in minimally invasive TKA is not clear.

Implant Survival, Knee Function, and Pain Relief After TKA: Are There Differences Between Men and Women?

Mary I. O’Connor MD

As efforts continue to improve the results of TKA, the potential influence of sex and gender on long-term survival of implants, knee function, pain relief, and patient satisfaction remains relevant, particularly given the increased incidence of osteoarthritis of the knee in women and reports that women derive equal benefit from TKA.

Do We Need Gender-specific Total Joint Arthroplasty?

Aaron J. Johnson MD, Christopher R. Costa MD, Michael A. Mont MD

Gender-specific differences in knee and hip anatomy have been well documented. Although it has been accepted these differences exist, there is controversy regarding if and how these differences should be addressed with gender-specific implant designs.

Clinical Cartilage Restoration: Evolution and Overview

Jack Farr MD, Brian Cole MD, MBA, Aman Dhawan MD, James Kercher MD, Seth Sherman MD

Clinical cartilage restoration is evolving, with established and emerging technologies. Randomized, prospective studies with adequate power comparing the myriad of surgical techniques used to treat chondral injuries are still lacking and it remains a challenge for the surgeon treating patients to make evidence-based decisions.