Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Infection 113 articles

Articles

Jeannette Wilkins Award: Can Locally Delivered Gadolinium Be Visualized on MRI? A Pilot Study

Morgan B. Giers BS, Chris S. Estes DO, Alex C. McLaren MD, Michael R. Caplan PhD, Ryan McLemore PhD

Management of orthopaedic infections relies on débridement and local delivery of antimicrobials; however, the distribution and concentration of locally delivered antimicrobials in postdébridement surgical sites is unknown. Gadolinium-DTPA (Gd-DTPA) has been proposed as an imaging surrogate for antimicrobials because it is similar in size and diffusion coefficient to gentamicin.

Does Dual Antibiotic Prophylaxis Better Prevent Surgical Site Infections in Total Joint Arthroplasty?

Amy Sewick MD, Amun Makani MD, Chia Wu MD, Judith O’Donnell MD, Keith D. Baldwin MD, MPH, MSPT, Gwo-Chin Lee MD

It is unclear which antibiotic regimen provides the best prophylaxis against surgical site infection (SSI) in patients undergoing hip and knee surgery.

Treatment of Early Postoperative Infections after THA: A Decision Analysis

Hany Bedair MD, Nicholas Ting MD, Kevin J. Bozic MD, MBA, Craig J. Della Valle MD, Scott M. Sporer MD

The treatment for an early postoperative periprosthetic infection after cementless THA that results in the highest quality of life after the control of infection is unknown. Although common treatments include irrigation and débridement with component retention, a one-stage exchange, or a two-stage exchange, it is unclear whether any of these provides a higher quality of life after the control of infection.

Are Bone and Serum Cefazolin Concentrations Adequate for Antimicrobial Prophylaxis?

Koji Yamada MD, Kunihiro Matsumoto PhD, Fumiaki Tokimura MD, Hiroshi Okazaki MD, PhD, Sakae Tanaka MD, PhD

Antimicrobial prophylaxis is considered beneficial for preventing surgical-site infections in clean orthopaedic surgery. However, whether tissue concentrations of cefazolin achieve the minimum inhibitory concentration for the targeted contaminants have yet to be clarified.

New Definition for Periprosthetic Joint Infection: From the Workgroup of the Musculoskeletal Infection Society

Javad Parvizi MD, Benjamin Zmistowski BS, Elie F. Berbari MD, Thomas W. Bauer MD, PhD, Bryan D. Springer MD, Craig J. Della Valle MD, Kevin L. Garvin MD, Michael A. Mont MD, Montri D. Wongworawat MD, Charalampos G. Zalavras MD

Antimicrobial Gauze as a Dressing Reduces Pin Site Infection: A Randomized Controlled Trial

C. K. Lee MBBS (U Malaya), Y. P. Chua MS Ortho (U Malaya), A. Saw FRCS (Edin)

Pin site infection is a common problem in external fixation. Plain gauze wetted with normal saline is commonly used for a pin site dressing owing to the simplicity and low cost. Evidence to support adding an antimicrobial agent in the dressing material is lacking.

Definition of Periprosthetic Joint Infection: Is There a Consensus?

Javad Parvizi MD, FRCS, Christina Jacovides BS, Benjamin Zmistowski BS, Kwang Am Jung MD

The diagnosis of periprosthetic joint infection (PJI) continues to pose a challenge. While many diagnostic criteria have been proposed, a gold standard for diagnosis is lacking. Use of multiple diagnostic criteria within the joint arthroplasty community raises concerns in patient treatment and comparison of research pertaining to PJI.

Sufficient Release of Antibiotic by a Spacer 6 Weeks after Implantation in Two-stage Revision of Infected Hip Prostheses

Bernd Fink MD, Sebastian Vogt PhD, Martin Reinsch PhD, Hubert Büchner PhD

Although antibiotic-loaded spacers are commonly used to treat periprosthetic infections, it is unclear whether spacers continue to release bactericidal levels of antibiotic 6 weeks after implantation.

Surfactant-stabilized Emulsion Increases Gentamicin Elution From Bone Cement

Ryan B. Miller MD, Alex C. McLaren MD, Christine M. Leon MS, Brent L. Vernon PhD, Ryan McLemore PhD

Liquid antimicrobial use for antimicrobial-loaded bone cement is limited because of decreased strength and small volume that can be loaded. Emulsifying the liquid antimicrobial into the monomer may address both issues.