Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Infection 116 articles


Treatment Solutions Are Unclear for Perimegaprosthetic Infections

Lisa B. Ercolano MD, Tyson Christensen BS, Richard McGough MD, Kurt Weiss MD

Infection about a megaprosthesis is a dreaded complication. Treatment options vary from débridement alone to staged revisions, arthrodesis, and amputation. Indications for how to treat this complication are unclear.

Impact of Preoperative MRSA Screening and Decolonization on Hospital-acquired MRSA Burden

Sapna Mehta MD, Scott Hadley MD, Lorraine Hutzler BA, James Slover MD, MS, Michael Phillips MD, Joseph A. Bosco MD

Hospital-acquired infections caused by methicillin-resistant(MRSA) are a source of morbidity and the most common pathogen in prosthetic joint infections and the incidence of MRSA is increasing.

Is Arthroplasty Immediately After an Infected Case a Risk Factor for Infection?

Mansour Abolghasemian MD, Amir Sternheim MD, Alireza Shakib MD, Oleg A. Safir MD, David Backstein MD

It is common practice in many centers to avoid performing a clean case in a room in which an infected procedure has just taken place. No studies of which we are aware speak to the necessity of this precaution.

Case Report: Artificial Elevation of Prothrombin Time by Telavancin

Derek F. Amanatullah MD, PhD, Matthew J. Lopez BS, Robert C. Gosselin CLS, Munish C. Gupta MD

Methicillin-resistant Staphylococcus aureus infections are a well-documented risk of surgery and are becoming increasingly difficult to treat owing to continued acquired resistance. A new antibiotic for treatment of Staphylococcus aureus is telavancin.

Bacteria Adhere Less to Barbed Monofilament Than Braided Sutures in a Contaminated Wound Model

John R. Fowler MD, Tiffany A. Perkins BS, Bettina A. Buttaro PhD, Allan L. Truant PhD

Previous studies have found fewer clinical infections in wounds closed with monofilament suture compared with braided suture. Recently, barbed monofilament sutures have shown improved strength and increased timesavings over interrupted braided sutures. However, the adherence of bacteria to barbed monofilament sutures and other commonly used suture materials is unclear.

High Diagnostic Value of Synovial Biopsy in Periprosthetic Joint Infection of the Hip

Bernd Fink MD, Alexander Gebhard MD, Martin Fuerst MD, Irina Berger MD, Peter Schäfer MD

The role of the synovial biopsy in the preoperative diagnosis of a periprosthetic joint infection (PJI) of the hip has not been clearly defined.

Does Dithiothreitol Improve Bacterial Detection from Infected Prostheses? A Pilot Study

Lorenzo Drago PhD, Carlo Luca Romanò MD, Roberto Mattina PhD, Valentina Signori BSc, Elena Vecchi MSc

Sonication and scraping of infected prostheses usually are used to improve diagnosis of prosthetic infections, reducing false negatives. Chemical methods that reduce biofilms also may allow higher levels of detection.

Low Rate of Infection Control in Enterococcal Periprosthetic Joint Infections

Mohammad R. Rasouli MD, Mohan S. Tripathi BA, Robert Kenyon BS, Nathan Wetters MD, Craig J. Della Valle MD, Javad Parvizi MD

Enterococcal periprosthetic joint infections (PJIs) are rare after joint arthroplasty. These cases are usually reported in series of PJIs caused by other pathogens. Because few studies have focused only on enterococcal PJIs, management and control of infection of these cases have not yet been well defined.

Mixing Method Affects Elution and Strength of High-dose ALBC: A Pilot Study

Ryan Miller MD, Alex McLaren MD, Christine Leon MS, Ryan McLemore PhD

High-dose antimicrobial-loaded bone cement (ALBC) is used to treat orthopaedic infections. High-dose ALBC is not commercially available and requires surgeon directed formulation, and there are several different methods used to mix high-dose ALBC.

Does a Prefabricated Gentamicin-impregnated, Load-bearing Spacer Control Periprosthetic Hip Infection?

Ryan M. Degen BSc, MD, John R. Davey BSc, J. Roderick Davey MD, FRCSC, James L. Howard MD, FRCSC, Richard W. McCalden MD, FRCSC, Douglas D. R. Naudie MD, FRCSC

Treating deep infection following THA has been a challenge. While the standard treatment has remained a two-stage revision, spacer designs, incorporated antibiotics, and concentrations have varied. Since control of infection may relate to choice and concentration of antibiotics, it is important to report rates of control from various spacers.