Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Infection 113 articles


Case Report: Artificial Elevation of Prothrombin Time by Telavancin

Derek F. Amanatullah MD, PhD, Matthew J. Lopez BS, Robert C. Gosselin CLS, Munish C. Gupta MD

Methicillin-resistant Staphylococcus aureus infections are a well-documented risk of surgery and are becoming increasingly difficult to treat owing to continued acquired resistance. A new antibiotic for treatment of Staphylococcus aureus is telavancin.

Bacteria Adhere Less to Barbed Monofilament Than Braided Sutures in a Contaminated Wound Model

John R. Fowler MD, Tiffany A. Perkins BS, Bettina A. Buttaro PhD, Allan L. Truant PhD

Previous studies have found fewer clinical infections in wounds closed with monofilament suture compared with braided suture. Recently, barbed monofilament sutures have shown improved strength and increased timesavings over interrupted braided sutures. However, the adherence of bacteria to barbed monofilament sutures and other commonly used suture materials is unclear.

High Diagnostic Value of Synovial Biopsy in Periprosthetic Joint Infection of the Hip

Bernd Fink MD, Alexander Gebhard MD, Martin Fuerst MD, Irina Berger MD, Peter Schäfer MD

The role of the synovial biopsy in the preoperative diagnosis of a periprosthetic joint infection (PJI) of the hip has not been clearly defined.

Does Dithiothreitol Improve Bacterial Detection from Infected Prostheses? A Pilot Study

Lorenzo Drago PhD, Carlo Luca Romanò MD, Roberto Mattina PhD, Valentina Signori BSc, Elena Vecchi MSc

Sonication and scraping of infected prostheses usually are used to improve diagnosis of prosthetic infections, reducing false negatives. Chemical methods that reduce biofilms also may allow higher levels of detection.

Low Rate of Infection Control in Enterococcal Periprosthetic Joint Infections

Mohammad R. Rasouli MD, Mohan S. Tripathi BA, Robert Kenyon BS, Nathan Wetters MD, Craig J. Della Valle MD, Javad Parvizi MD

Enterococcal periprosthetic joint infections (PJIs) are rare after joint arthroplasty. These cases are usually reported in series of PJIs caused by other pathogens. Because few studies have focused only on enterococcal PJIs, management and control of infection of these cases have not yet been well defined.

Mixing Method Affects Elution and Strength of High-dose ALBC: A Pilot Study

Ryan Miller MD, Alex McLaren MD, Christine Leon MS, Ryan McLemore PhD

High-dose antimicrobial-loaded bone cement (ALBC) is used to treat orthopaedic infections. High-dose ALBC is not commercially available and requires surgeon directed formulation, and there are several different methods used to mix high-dose ALBC.

Does a Prefabricated Gentamicin-impregnated, Load-bearing Spacer Control Periprosthetic Hip Infection?

Ryan M. Degen BSc, MD, John R. Davey BSc, J. Roderick Davey MD, FRCSC, James L. Howard MD, FRCSC, Richard W. McCalden MD, FRCSC, Douglas D. R. Naudie MD, FRCSC

Treating deep infection following THA has been a challenge. While the standard treatment has remained a two-stage revision, spacer designs, incorporated antibiotics, and concentrations have varied. Since control of infection may relate to choice and concentration of antibiotics, it is important to report rates of control from various spacers.

Do Dynamic Cement-on-Cement Knee Spacers Provide Better Function and Activity During Two-stage Exchange?

David J. Jaekel MS, Judd S. Day PhD, Gregg R. Klein MD, Harlan Levine MD, Javad Parvizi MD, Steven M. Kurtz PhD

Implantation of an antibiotic bone cement spacer is used to treat infection of a TKA. Dynamic spacers fashioned with cement-on-cement articulating surfaces potentially facilitate patient mobility and reduce bone loss as compared with their static counterparts, while consisting of a biomaterial not traditionally used for load-bearing articulations. However, their direct impact on patient mobility and wear damage while implanted remains poorly understood.

Better Function for Fusions Versus Above-the-knee Amputations for Recurrent Periprosthetic Knee Infection

Antonia F. Chen MD, MBA, Nicholas C. Kinback BS, Alma E. Heyl LAS, RTR, CCRC, Edward J. McClain MD, Brian A. Klatt MD

Treatment of chronic periprosthetic joint infections (PJIs) after TKA is limited to fusions, above-the-knee amputations (AKAs), revision TKA, and antibiotic suppression and is often based on the patient’s medical condition. However, when both fusion and AKA are options, it is important to compare these two procedures with regard to function.

Liposomal Formulation Increases Local Delivery of Amphotericin from Bone Cement: A Pilot Study

Brian Cunningham MD, Alex C. McLaren MD, Christine Pauken PhD, Ryan McLemore PhD

Amphotericin is a highly toxic hydrophobic antifungal. Delivery of amphotericin from antifungal-loaded bone cement (ALBC) is much lower than would be expected for an equivalent load of water-soluble antibacterials. Lipid formulations have been developed to decrease amphotericin toxicity. It is unknown how lipid formulations affect amphotericin release and compressive strength of amphotericin ALBC.