Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Infection 119 articles


Staphylococcus aureus Colonization among Arthroplasty Patients Previously Treated by a Decolonization Protocol: A Pilot Study

Demetri M. Economedes DO, Gregory K. Deirmengian MD, Carl A. Deirmengian MD

Although testing and treatment forcolonization before total joint arthroplasty (TJA) are well described and understood, the durability of decolonization has not been studied extensively.

Cyanoacrylate Microbial Sealant May Reduce the Prevalence of Positive Cultures in Revision Shoulder Arthroplasty

Adam J. Lorenzetti MD, Montri D. Wongworawat MD, Christopher M. Jobe MD, Wesley P. Phipatanakul MD

Cyanoacrylate-based, microbial sealant is an adhesive skin barrier designed to prevent bacterial contamination in surgical wounds. This type of adhesive barrier could have use in decreasing the incidence of positive cultures and subsequent infection in shoulder arthroplasty.

Distribution of Locally Delivered Antimicrobials Is Limited by Cortical Bone: A Pilot Study

Ryan Odgers MD, Keith Jarbo MD, Alex McLaren MD, Ryan McLemore PhD

Local delivery is required to achieve the high antimicrobial concentrations needed to treat biofilm-forming infections. The delivery site is commonly either in the intramedullary canal or at the periosteal surface. It is unknown whether locally delivered antimicrobials are transported transcortically between the endosteal and periosteal surfaces when the infection involves the opposite surface.

Treatment Solutions Are Unclear for Perimegaprosthetic Infections

Lisa B. Ercolano MD, Tyson Christensen BS, Richard McGough MD, Kurt Weiss MD

Infection about a megaprosthesis is a dreaded complication. Treatment options vary from débridement alone to staged revisions, arthrodesis, and amputation. Indications for how to treat this complication are unclear.

Impact of Preoperative MRSA Screening and Decolonization on Hospital-acquired MRSA Burden

Sapna Mehta MD, Scott Hadley MD, Lorraine Hutzler BA, James Slover MD, MS, Michael Phillips MD, Joseph A. Bosco MD

Hospital-acquired infections caused by methicillin-resistant(MRSA) are a source of morbidity and the most common pathogen in prosthetic joint infections and the incidence of MRSA is increasing.

Is Arthroplasty Immediately After an Infected Case a Risk Factor for Infection?

Mansour Abolghasemian MD, Amir Sternheim MD, Alireza Shakib MD, Oleg A. Safir MD, David Backstein MD

It is common practice in many centers to avoid performing a clean case in a room in which an infected procedure has just taken place. No studies of which we are aware speak to the necessity of this precaution.

Case Report: Artificial Elevation of Prothrombin Time by Telavancin

Derek F. Amanatullah MD, PhD, Matthew J. Lopez BS, Robert C. Gosselin CLS, Munish C. Gupta MD

Methicillin-resistant Staphylococcus aureus infections are a well-documented risk of surgery and are becoming increasingly difficult to treat owing to continued acquired resistance. A new antibiotic for treatment of Staphylococcus aureus is telavancin.

Bacteria Adhere Less to Barbed Monofilament Than Braided Sutures in a Contaminated Wound Model

John R. Fowler MD, Tiffany A. Perkins BS, Bettina A. Buttaro PhD, Allan L. Truant PhD

Previous studies have found fewer clinical infections in wounds closed with monofilament suture compared with braided suture. Recently, barbed monofilament sutures have shown improved strength and increased timesavings over interrupted braided sutures. However, the adherence of bacteria to barbed monofilament sutures and other commonly used suture materials is unclear.

High Diagnostic Value of Synovial Biopsy in Periprosthetic Joint Infection of the Hip

Bernd Fink MD, Alexander Gebhard MD, Martin Fuerst MD, Irina Berger MD, Peter Schäfer MD

The role of the synovial biopsy in the preoperative diagnosis of a periprosthetic joint infection (PJI) of the hip has not been clearly defined.

Does Dithiothreitol Improve Bacterial Detection from Infected Prostheses? A Pilot Study

Lorenzo Drago PhD, Carlo Luca Romanò MD, Roberto Mattina PhD, Valentina Signori BSc, Elena Vecchi MSc

Sonication and scraping of infected prostheses usually are used to improve diagnosis of prosthetic infections, reducing false negatives. Chemical methods that reduce biofilms also may allow higher levels of detection.