Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Infection 113 articles


Tuberculosis of the Pubic Symphysis: Four Unusual Cases and Literature Review

Hitesh Lal MS, Vijay Kumar Jain MS, Sudhir Kannan MS

The incidence of extrapulmonary tuberculosis (TB) has increased in the chemotherapeutic era owing to the increasing presence of immunodeficiency disorders. Pubic symphysis TB, although uncommon, is again important as these infections once were in the prechemotherapeutic era.

What Is the Success of Treatment of Hip and Knee Candidal Periprosthetic Joint Infection?

Steve W. N. Ueng MD, Ching-Yu Lee MD, Chih-chien Hu MD, Pang-Hsin Hsieh MD, Yuhan Chang MD, PhD

Fungal infection at an arthroplasty site is rare and poses a therapeutic challenge. To the best of our knowledge, no reports have been published thus far on the success rate of prosthesis reimplantation after fungal prosthetic joint infections.

Novel Biomarkers to Detect Infection in Revision Hip and Knee Arthroplasties

Mathias Glehr MD, Joerg Friesenbichler MD, Günter Hofmann MD, Gerwin Alexander Bernhardt MD, Maximilian Zacherl MD, Alexander Avian PhD, Reinhard Windhager MD, Andreas Leithner MD

A periprosthetic joint infection is one of the most challenging complications associated with THA and TKA. In the diagnostic process for detecting a periprosthetic joint infection, one of the most important steps is analysis of laboratory infection biomarkers.

Chitosan Sponges for Local Synergistic Infection Therapy: A Pilot Study

J. Keaton Smith MS, Abteen R. Moshref BS, Jessica A. Jennings PhD, Harry S. Courtney PhD, Warren O. Haggard PhD

Although bacterial antibiotic resistance is increasing, fewer new antibiotics are being developed to compensate. Localized delivery of synergistic antiseptics and antibiotics with a chitosan sponge device may offer an alternative infection treatment.

Swab Cultures Are Not As Effective As Tissue Cultures for Diagnosis of Periprosthetic Joint Infection

Vinay K. Aggarwal BS, Carlos Higuera MD, Gregory Deirmengian MD, Javad Parvizi MD, FRCS, Matthew S. Austin MD

While it is accepted accurate identification of infecting organisms is crucial in guiding treatment of periprosthetic joint infection (PJI), there remains no consensus regarding the best method for obtaining cultures.

Has the Rate of In-hospital Infections After Total Joint Arthroplasty Decreased?

Mohammad R. Rasouli MD, Mitchell Gil Maltenfort PhD, James J. Purtill MD, William J. Hozack MD, Javad Parvizi MD

Although infections are a major cause of morbidity and mortality after total joint arthroplasty (TJA), little is known about nationwide epidemiology and trends of infections after TJA.

Negative Pressure Wound Therapy Is Associated With Resolution of Incisional Drainage in Most Wounds After Hip Arthroplasty

Erik Hansen MD, Joel B. Durinka MD, James A. Costanzo MD, Matthew S. Austin MD, Gregory K. Deirmengian MD

Persistent wound drainage after hip arthroplasty is a risk factor for periprosthetic infection. Negative pressure wound therapy (NPWT) has been used in other fields for wound management although it is unclear whether the technique is appropriate for total hip arthroplasty.

Medical Comorbidities Are Independent Preoperative Risk Factors for Surgical Infection After Total Joint Arthroplasty

Joshua S. Everhart BS, Eric Altneu MS, Jason H. Calhoun MD

Surgical site infection (SSI) after total joint arthroplasty (TJA) is a major cause of morbidity. Multiple patient comorbidities have been identified as SSI risk factors including obesity, tobacco use, diabetes, immunosuppression, malnutrition, and coagulopathy. However, the independent effect of multiple individual patient factors on risk of subsequent periprosthetic infection is unclear.

No Infection Reduction Using Chlorhexidine Wipes in Total Joint Arthroplasty

Nicholas J. Farber BS, Antonia F. Chen MD, MBA, Sarah M. Bartsch MPH, Jody L. Feigel MSN, RN, Brian A. Klatt MD

Surgical site infection (SSI) after total joint arthroplasty (TJA) is a rare but devastating complication. Various skin antiseptic applications are used preoperatively to prevent SSI. Recent literature suggests 2% chlorhexidine gluconate (CHG) wipes reduce microbial content at surgical sites, but it is unclear whether they reduce rates of SSI.

The Routine Use of Atypical Cultures in Presumed Aseptic Revisions Is Unnecessary

Anthony T. Tokarski BS, Joseph O’Neil MD, Carl A. Deirmengian MD, Joseph Ferguson BS, Gregory K. Deirmengian MD

In presumed aseptic hip and knee revisions, it is common practice to send intraoperative cultures to screen for occult infection. Currently no guidelines exist for the routine use of acid-fast bacillus (AFB) and fungal cultures in this setting.