Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Infection 116 articles


d -amino Acid Inhibits Biofilm but not New Bone Formation in an Ovine Model

Andrew J. Harmata PhD, Yun Ma PhD, Carlos J. Sanchez PhD, Katarzyna J. Zienkiewicz MS, Florent Elefteriou PhD, Joseph C. Wenke PhD, Scott A. Guelcher PhD

Infectious complications of musculoskeletal trauma are an important factor contributing to patient morbidity. Biofilm-dispersive bone grafts augmented with-amino acids (-AAs) prevent biofilm formation in vitro and in vivo, but the effects of-AAs on osteocompatibility and new bone formation have not been investigated.

Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA

Simon W. Young FRACS, Tim Roberts MBChB, Sarah Johnson BSc, James P. Dalton PhD, Brendan Coleman FRACS, Siouxsie Wiles PhD

In human TKA studies, intraosseous regional administration (IORA) of prophylactic antibiotics achieves local tissue antibiotic concentrations 10 times greater than systemic administration. However, it is unclear if such high concentrations provide more effective prophylaxis.

Treatment of Periprosthetic Knee Infection With a Two-stage Protocol Using Static Spacers

Paul Lichstein MD, MS, Sharlene Su BS, Hakan Hedlund MD, PhD, Gina Suh MD, William J. Maloney MD, Stuart B. Goodman MD, PhD, James I. Huddleston MD

Two-stage exchange arthroplasty is a standard approach for treating total knee arthroplasty periprosthetic joint infection in the United States, but whether this should be performed with a static antibiotic spacer or an articulating one that allows range of motion before reimplantation remains controversial. It is unclear if the advantages of articulating spacers (easier surgical exposure during reimplantation and improved postoperative flexion) outweigh the disadvantages of increased cost and complexity in the setting of similar rates of infection eradication.

Can Good Infection Control Be Obtained in One-stage Exchange of the Infected TKA to a Rotating Hinge Design? 10-year Results

Akos Zahar MD, Daniel O. Kendoff MD, PhD, Till O. Klatte MD, Thorsten A. Gehrke MD

Prosthetic joint infection (PJI) occurs in 1% to 2% of total knee arthroplasties (TKAs). Although two-stage exchange is the preferred management method of patients with chronic PJI in TKA in North America, one-stage exchange is an alternative treatment method, but long-term studies of this approach have not been conducted.

A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis

Kohei Nishitani MD, PhD, Christopher A. Beck PhD, Alexander F. Rosenberg PhD, Stephen L. Kates MD, Edward M. Schwarz PhD, John L. Daiss PhD

Because immunity againsthas not been fully elucidated, there is no diagnostic test to gauge how robust a patient’s host response is likely to be. Therefore, we aimed to develop a test for specific antibodies in serum with diagnostic and prognostic potential.

Can Normal Fracture Healing Be Achieved When the Implant Is Retained on the Basis of Infection? An Experimental Animal Model

Fuat Bilgili MD, Halil Ibrahim Balci MD, Kayahan Karaytug MD, Kerim Sariyilmaz MD, Ata Can Atalar MD, Ergun Bozdag PhD, Meral Tuna PhD, Bilge Bilgic MD, Nezahat Gurler MD

Infection after open fractures is a common complication. Treatment options for infections developed after intramedullary nailing surgery remain a topic of controversy. We therefore used a rat fracture model to evaluate the effects of infection on osseous union when the implant was maintained.

Cathodic Electrical Stimulation Combined With Vancomycin Enhances Treatment of Methicillin-resistant Staphylococcus aureus Implant-associated Infections

Scott Nodzo MD, Menachem Tobias MS, Lisa Hansen MS, Nicole R. Luke-Marshall PhD, Ross Cole BS, Linda Wild MD, Anthony A. Campagnari PhD, Mark T. Ehrensberger PhD

Effective treatments for implant-associated infections are often lacking. Cathodic voltage-controlled electrical stimulation has shown potential as a treatment of implant-associated infections of methicillin-resistant(MRSA).

Liposomal Formulation Decreases Toxicity of Amphotericin B In Vitro and In Vivo

Justin Roberts MD, Josh Bingham MD, Alex C. McLaren MD, Ryan McLemore PhD

Liposomal amphotericin B is locally delivered to treat fungal orthopaedic infections but little is known about local tissue toxicity, if any, that might be associated with local delivery.

A History of Treated Periprosthetic Joint Infection Increases the Risk of Subsequent Different Site Infection

Hany Bedair MD, Nitin Goyal MD, Mathew J. Dietz MD, Kenneth Urish MD, PhD, Viktor Hansen MD, Jorge Manrique MD, William Hamilton MD, Greg Deirmengian MD

After the successful treatment of periprosthetic joint infection (PJI), patients may present with degenerative joint disease in another joint with symptoms severe enough to warrant arthroplasty. However, it is not known whether patients with a history of treated PJI at one site will have an increased risk of PJI in the second arthroplasty site.

Are Nucleated Cell Counts Useful in the Diagnosis of Infection in Periprosthetic Fracture?

Stephen Preston MD, Lyndsay Somerville PhD, Brent Lanting MD, James Howard MD

Evaluating for the possibility of prosthetic joint infection in the setting of periprosthetic fracture is important because it determines the course of treatment. However, fracture-related inflammation can make investigations used in the diagnosis of infection less reliable.