Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Basic Research 173 articles


Mesenchymal Stem Cells in Synovial Fluid Increase After Meniscus Injury

Yu Matsukura MD, Takeshi Muneta MD, PhD, Kunikazu Tsuji PhD, Hideyuki Koga MD, PhD, Ichiro Sekiya MD, PhD

Although relatively uncommon, spontaneous healing from a meniscus injury has been observed even within the avascular area. This may be the result of the existence of mesenchymal stem cells in synovial fluid.

Patients With Hip Osteoarthritis Have a Phenotype With High Bone Mass and Low Lean Body Mass

Magnus K. Karlsson MD, PhD, Håkan Magnusson MD, PhD, Maria C. Cöster MD, Tord vonSchewelov MD, PhD, Caroline Karlsson MD, PhD, Björn E. Rosengren MD, PhD

Although hip osteoarthritis (OA) is common, its etiology is poorly understood. Specifically, it is not known whether hip OA is associated with abnormal relationships among the anthropometric and musculoskeletal characteristics that are associated with OA in general.

Progression of Bone Ingrowth and Attachment Strength for Stability of Percutaneous Osseointegrated Prostheses

Sujee Jeyapalina PhD, J. Peter Beck MD, Roy D. Bloebaum PhD, Kent N. Bachus PhD

Percutaneous osseointegrated prosthetic (POP) devices have been used clinically in Europe for decades. Unfortunately, their introduction into the United States has been delayed, in part due to the lack of data documenting the progression of osseointegration and mechanical stability.

Loss of Cement-bone Interlock in Retrieved Tibial Components from Total Knee Arthroplasties

Mark A. Miller MS, Jacklyn R. Goodheart BS, Timothy H. Izant MD, Clare M. Rimnac PhD, Richard J. Cleary PhD, Kenneth A. Mann PhD

Aseptic loosening continues to be a short- and long-term complication for patients with cemented TKAs. Most studies to this point have evaluated tibial component fixation via radiographic changes at the implant-bone interface and quantification of component migration; direct assessment of morphologic features of the interface from functioning TKAs may provide new information regarding how TKAs function and are fixed to bone.

Tracked Ultrasound Snapshots in Percutaneous Pedicle Screw Placement Navigation: A Feasibility Study

Tamas Ungi MD, PhD, Eric Moult BSc, Joseph H. Schwab MD, Gabor Fichtinger PhD

Computerized navigation improves the accuracy of minimally invasive pedicle screw placement during spine surgery. Such navigation, however, exposes both the patient and the staff to radiation during surgery. To avoid intraoperative exposure to radiation, tracked ultrasound snapshots—ultrasound image frames coupled with corresponding spatial positions—could be used to map preoperatively defined screw plans into the intraoperative coordinate frame. The feasibility of such an approach, however, has not yet been investigated.

Amount of Torque and Duration of Stretching Affects Correction of Knee Contracture in a Rat Model of Spinal Cord Injury

Hideki Moriyama PhD, Yoshiko Tobimatsu PhD, Junya Ozawa PhD, Nobuhiro Kito PhD, Ryo Tanaka PhD

Joint contractures are a common complication of many neurologic conditions, and stretching often is advocated to prevent and treat these contractures. However, the magnitude and duration of the stretching done in practice usually are guided by subjective clinical impressions.

No Effect of Hole Geometry in Microfracture for Talar Osteochondral Defects

Aimee Claire Kok MD, Gabrielle J. M. Tuijthof PhD, Steven Dunnen MSc, Jasper Tiel MD, Michiel Siebelt MD, Vincent Everts PhD, C. Niek Dijk PhD, MD, Gino M. M. J. Kerkhoffs PhD, MD

Débridement and bone marrow stimulation is an effective treatment option for patients with talar osteochondral defects. However, whether surgical factors affect the success of microfracture treatment of talar osteochondral defects is not well characterized.

Have Levels of Evidence Improved the Quality of Orthopaedic Research?

Brian P. Cunningham MD, Samuel Harmsen MD, Chris Kweon MD, Jason Patterson MD, Robert Waldrop MD, Alex McLaren MD, Ryan McLemore PhD

Since 2003 many orthopaedic journals have adopted grading systems for levels of evidence (LOE). It is unclear if the quality of orthopaedic literature has changed since LOE was introduced.

Loss of SS18-SSX1 Inhibits Viability and Induces Apoptosis in Synovial Sarcoma

Emily E. Carmody Soni MD, Silke Schlottman PhD, Hayriye V. Erkizan PhD, Aykut Uren MD, Jeffrey A. Toretsky MD

Most synovial sarcomas contain a chromosomal translocation t(X;18), which results in the formation of an oncoprotein SS18-SSX critical to the viability of synovial sarcoma.

The Peripheral Neuronal Phenotype is Important in the Pathogenesis of Painful Human Tendinopathy: A Systematic Review

Benjamin John Floyd Dean MRCS (Ed), Sarah L. Franklin PhD, Andrew Jonathan Carr FRCS, FMedSci

The pathogenesis of tendinopathy is complex and incompletely understood. Although significant advances have been made in terms of understanding the pathological changes in both the extracellular matrix and the cells involved, relatively little is known about the role of neuronal regulation in tendinopathy. The frequent mismatch between tendon pathology and pain may be explained, in part, by differences in the peripheral neuronal phenotype of patients.