Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Basic Research 169 articles


Tracked Ultrasound Snapshots in Percutaneous Pedicle Screw Placement Navigation: A Feasibility Study

Tamas Ungi MD, PhD, Eric Moult BSc, Joseph H. Schwab MD, Gabor Fichtinger PhD

Computerized navigation improves the accuracy of minimally invasive pedicle screw placement during spine surgery. Such navigation, however, exposes both the patient and the staff to radiation during surgery. To avoid intraoperative exposure to radiation, tracked ultrasound snapshots—ultrasound image frames coupled with corresponding spatial positions—could be used to map preoperatively defined screw plans into the intraoperative coordinate frame. The feasibility of such an approach, however, has not yet been investigated.

Amount of Torque and Duration of Stretching Affects Correction of Knee Contracture in a Rat Model of Spinal Cord Injury

Hideki Moriyama PhD, Yoshiko Tobimatsu PhD, Junya Ozawa PhD, Nobuhiro Kito PhD, Ryo Tanaka PhD

Joint contractures are a common complication of many neurologic conditions, and stretching often is advocated to prevent and treat these contractures. However, the magnitude and duration of the stretching done in practice usually are guided by subjective clinical impressions.

No Effect of Hole Geometry in Microfracture for Talar Osteochondral Defects

Aimee Claire Kok MD, Gabrielle J. M. Tuijthof PhD, Steven Dunnen MSc, Jasper Tiel MD, Michiel Siebelt MD, Vincent Everts PhD, C. Niek Dijk PhD, MD, Gino M. M. J. Kerkhoffs PhD, MD

Débridement and bone marrow stimulation is an effective treatment option for patients with talar osteochondral defects. However, whether surgical factors affect the success of microfracture treatment of talar osteochondral defects is not well characterized.

Have Levels of Evidence Improved the Quality of Orthopaedic Research?

Brian P. Cunningham MD, Samuel Harmsen MD, Chris Kweon MD, Jason Patterson MD, Robert Waldrop MD, Alex McLaren MD, Ryan McLemore PhD

Since 2003 many orthopaedic journals have adopted grading systems for levels of evidence (LOE). It is unclear if the quality of orthopaedic literature has changed since LOE was introduced.

Loss of SS18-SSX1 Inhibits Viability and Induces Apoptosis in Synovial Sarcoma

Emily E. Carmody Soni MD, Silke Schlottman PhD, Hayriye V. Erkizan PhD, Aykut Uren MD, Jeffrey A. Toretsky MD

Most synovial sarcomas contain a chromosomal translocation t(X;18), which results in the formation of an oncoprotein SS18-SSX critical to the viability of synovial sarcoma.

The Peripheral Neuronal Phenotype is Important in the Pathogenesis of Painful Human Tendinopathy: A Systematic Review

Benjamin John Floyd Dean MRCS (Ed), Sarah L. Franklin PhD, Andrew Jonathan Carr FRCS, FMedSci

The pathogenesis of tendinopathy is complex and incompletely understood. Although significant advances have been made in terms of understanding the pathological changes in both the extracellular matrix and the cells involved, relatively little is known about the role of neuronal regulation in tendinopathy. The frequent mismatch between tendon pathology and pain may be explained, in part, by differences in the peripheral neuronal phenotype of patients.

Is There an Epidemic Vitamin D Deficiency in German Orthopaedic Patients?

Gerrit Steffen Maier MD, Philipp Jakobs, Klaus Edgar Roth MD, Andreas Alois Kurth MD, Uwe Maus MD

Vitamin D plays an essential role in bone health and muscle function. Some studies have shown a widespread rate of vitamin D deficiency in the general population, but few have reported on the vitamin D status of orthopaedic patients.

Relationship of Relaxin Hormone and Thumb Carpometacarpal Joint Arthritis

Jennifer Moriatis Wolf MD, Danielle L. Scher MD, Eric W. Etchill MPH, Frank Scott MD, Allison E. Williams PhD, Steven Delaronde MPH, MSW, Karen B. King PhD

The female predominance in thumb carpometacarpal (CMC) joint arthritis has led to speculation that reproductive hormones or hypermobility are responsible. Evidence shows that patients with pathologic laxity have a higher rate of thumb CMC arthritis. Relaxin hormone increases laxity in the pelvic ligaments through upregulation of matrix metalloproteases (MMPs). It is thus a hormone of interest in the development of thumb CMC arthritis.

A Daptomycin-Xylitol-loaded Polymethylmethacrylate Bone Cement: How Much Xylitol Should Be Used?

Ali Salehi MS, Ashley Cox Parker MS, Gladius Lewis PhD, Harry S. Courtney PhD, Warren O. Haggard PhD

The rate of release of an antibiotic from an antibiotic-loaded polymethylmethacrylate (PMMA) bone cement is low. This may be increased by adding a particulate poragen (eg, xylitol) to the cement powder. However, the appropriate poragen amount is unclear.

Cumulative Effects of Bone and Soft Tissue Injury on Systemic Inflammation: A Pilot Study

Roman Pfeifer MD, Sophie Darwiche MD, Lauryn Kohut MA, Timothy R. Billiar MD, FACS, Hans-Christoph Pape MD, FACS

In multiply injured patients, bilateral femur fractures invoke a substantial systemic inflammatory impact and remote organ dysfunction. However, it is unclear whether isolated bone or soft tissue injury contributes to the systemic inflammatory response and organ injury after fracture.