Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Basic Research 173 articles


Calcium Phosphate Cement with BMP-2-loaded Gelatin Microspheres Enhances Bone Healing in Osteoporosis: A Pilot Study

Meng Li MD, Xingyan Liu MD, Xudong Liu MD, Baofeng Ge MD

The capacity for bone healing reportedly is limited in osteoporosis with a less than ideal environment for healing of bone grafts. We therefore developed a composite bone substitute with rhBMP-2 loaded gelatin microsphere (GM) and calcium phosphate cement (CPC) to use in osteoporosis.

Maggot Excretions Inhibit Biofilm Formation on Biomaterials

Gwendolyn Cazander MD, Mariëlle C. Veerdonk, Christina M. J. E. Vandenbroucke-Grauls MD, PhD, Marco W. J. Schreurs PhD, Gerrolt N. Jukema MD, PhD

Biofilm-associated infections in trauma surgery are difficult to treat with conventional therapies. Therefore, it is important to develop new treatment modalities. Maggots in captured bags, which are permeable for larval excretions/secretions, aid in healing severe, infected wounds, suspect for biofilm formation. Therefore we presumed maggot excretions/secretions would reduce biofilm formation.

N-acetylcysteine Protects Striated Muscle in a Model of Compartment Syndrome

Stephen R. Kearns FRCS (Tr&Orth), David E. O’Briain IMRCS, Katherine M. Sheehan MD, Cathal Kelly FRCSI (Gen), David Bouchier-Hayes FRCSI

To avoid ischemic necrosis, compartment syndrome is a surgical emergency treated with decompression once identified. A potentially lethal, oxidant-driven reperfusion injury occurs after decompression. N-acetylcysteine is an antioxidant with the potential to attenuate the reperfusion injury.