Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Basic Research 173 articles


Raman Assessment of Bone Quality

Michael D. Morris PhD, Gurjit S. Mandair PhD

Progress in the diagnosis and prediction of fragility fractures depends on improvements to the understating of the compositional contributors of bone quality to mechanical competence. Raman spectroscopy has been used to evaluate alterations to bone composition associated with aging, disease, or injury.

Emerging Ideas: Interleukin-12 Nanocoatings Prevent Open Fracture-associated Infections

Bingyun Li PhD, Anne L. McKeague PhD

Infection is a major clinical complication of orthopaedic implants and prosthetic devices, and patients with traumatic open fractures have a high risk of infection that may exceed 30%. Surgical trauma, burns, and major injuries such as traumatic open fractures induce immunosuppression, decrease resistance to infection, and decrease production of T helper type 1 (Th1) cytokines.

Emerging Ideas: Soft Tissue Applications of Radiostereometric Analysis

Lucian B. Solomon MD, PhD, FRACS, Stuart A. Callary BAppSc

Currently, the movement that occurs at the site of soft tissue repair cannot be measured accurately in vivo. Radiostereometric analysis (RSA) is the gold standard for measuring movement between two skeletal segments in vivo but its application to studying soft tissue migration has been limited by the unknown stability of tantalum beads in tendons and ligaments and their ability to define rigid bodies in these structures.

The Accuracy of Digital Radiography in Orthopaedic Applications

John R. Fowler MD, Asif M. Ilyas MD

Recent advances in technology and the use of image archiving and communication systems (PACS) has led some institutions to abandon conventional plain film radiography and rely solely on digital computed radiography. The level of accuracy of digital radiography in measuring distances for orthopaedic applications is unclear.

Osteogenic Protein-1 Delivered by Hydroxyapatite-coated Implants Improves Bone Ingrowth in Extracortical Bone Bridging

Neil Saran MD, FRCSC, Renwen Zhang MD, PhD, Robert E. Turcotte MD, FRCSC

Extracortical bone bridging for treatment of massive bone loss can improve stability and longevity of massive endoprostheses. Osteogenic protein-1 (OP-1), when used with allograft bone, reportedly improves extracortical bone bridging and bone ingrowth.

Shed Blood-derived Cells from Total Hip Arthroplasty Have Osteoinductive Potential: A Pilot Study

Tomokazu Yoshida MD, Masakazu Ishikawa MD, PhD, Yuji Yasunaga MD, PhD, Takuma Yamasaki MD, PhD, Mitsuo Ochi MD, PhD

Cell therapy using autologous cells has been used in the treatment of various medical conditions. The mononuclear cell (MNC) fraction of bone marrow (BM) contains stem/progenitor cells that could contribute to osteogenesis and angiogenesis.

In Vivo and In Vitro Analysis of Rat Lumbar Spine Mechanics

Matthew E. Cunningham MD, PhD, Jocelyn M. Beach BS, Serkan Bilgic MD, Oheneba Boachie-Adjei MD, Marjolein C. H. Meulen PhD, Chisa Hidaka MD

Rodent lumbar and caudal (tail) spine segments provide useful in vivo and in vitro models for human disc research. In vivo caudal models allow characterization of the effect of static and dynamic loads on disc mechanics of individual animals with time, but the lumbar models have required sacrifice of the animals for in vitro mechanical testing.

2010 Nicolas Andry Award: Multipotent Adult Stem Cells from Adipose Tissue for Musculoskeletal Tissue Engineering

Farshid Guilak, Bradley T. Estes, Brian O. Diekman, Franklin T. Moutos, Jeffrey M. Gimble

Cell-based therapies such as tissue engineering provide promising therapeutic possibilities to enhance the repair or regeneration of damaged or diseased tissues but are dependent on the availability and controlled manipulation of appropriate cell sources.

Effects of Pulsed Electromagnetic Fields on Human Osteoblastlike Cells (MG-63): A Pilot Study

Vincenzo Sollazzo MD, Annalisa Palmieri PhD, Furio Pezzetti PhD, Leo Massari MD, Francesco Carinci MD

Although pulsed electromagnetic fields (PEMFs) are used to treat delayed unions and nonunions, their mechanisms of action are not completely clear. However, PEMFs are known to affect the expression of certain genes.