Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Basic Research 169 articles


Osteogenic Protein-1 Delivered by Hydroxyapatite-coated Implants Improves Bone Ingrowth in Extracortical Bone Bridging

Neil Saran MD, FRCSC, Renwen Zhang MD, PhD, Robert E. Turcotte MD, FRCSC

Extracortical bone bridging for treatment of massive bone loss can improve stability and longevity of massive endoprostheses. Osteogenic protein-1 (OP-1), when used with allograft bone, reportedly improves extracortical bone bridging and bone ingrowth.

Shed Blood-derived Cells from Total Hip Arthroplasty Have Osteoinductive Potential: A Pilot Study

Tomokazu Yoshida MD, Masakazu Ishikawa MD, PhD, Yuji Yasunaga MD, PhD, Takuma Yamasaki MD, PhD, Mitsuo Ochi MD, PhD

Cell therapy using autologous cells has been used in the treatment of various medical conditions. The mononuclear cell (MNC) fraction of bone marrow (BM) contains stem/progenitor cells that could contribute to osteogenesis and angiogenesis.

In Vivo and In Vitro Analysis of Rat Lumbar Spine Mechanics

Matthew E. Cunningham MD, PhD, Jocelyn M. Beach BS, Serkan Bilgic MD, Oheneba Boachie-Adjei MD, Marjolein C. H. Meulen PhD, Chisa Hidaka MD

Rodent lumbar and caudal (tail) spine segments provide useful in vivo and in vitro models for human disc research. In vivo caudal models allow characterization of the effect of static and dynamic loads on disc mechanics of individual animals with time, but the lumbar models have required sacrifice of the animals for in vitro mechanical testing.

2010 Nicolas Andry Award: Multipotent Adult Stem Cells from Adipose Tissue for Musculoskeletal Tissue Engineering

Farshid Guilak, Bradley T. Estes, Brian O. Diekman, Franklin T. Moutos, Jeffrey M. Gimble

Cell-based therapies such as tissue engineering provide promising therapeutic possibilities to enhance the repair or regeneration of damaged or diseased tissues but are dependent on the availability and controlled manipulation of appropriate cell sources.

Effects of Pulsed Electromagnetic Fields on Human Osteoblastlike Cells (MG-63): A Pilot Study

Vincenzo Sollazzo MD, Annalisa Palmieri PhD, Furio Pezzetti PhD, Leo Massari MD, Francesco Carinci MD

Although pulsed electromagnetic fields (PEMFs) are used to treat delayed unions and nonunions, their mechanisms of action are not completely clear. However, PEMFs are known to affect the expression of certain genes.

Calcium Phosphate Cement with BMP-2-loaded Gelatin Microspheres Enhances Bone Healing in Osteoporosis: A Pilot Study

Meng Li MD, Xingyan Liu MD, Xudong Liu MD, Baofeng Ge MD

The capacity for bone healing reportedly is limited in osteoporosis with a less than ideal environment for healing of bone grafts. We therefore developed a composite bone substitute with rhBMP-2 loaded gelatin microsphere (GM) and calcium phosphate cement (CPC) to use in osteoporosis.

Maggot Excretions Inhibit Biofilm Formation on Biomaterials

Gwendolyn Cazander MD, Mariëlle C. Veerdonk, Christina M. J. E. Vandenbroucke-Grauls MD, PhD, Marco W. J. Schreurs PhD, Gerrolt N. Jukema MD, PhD

Biofilm-associated infections in trauma surgery are difficult to treat with conventional therapies. Therefore, it is important to develop new treatment modalities. Maggots in captured bags, which are permeable for larval excretions/secretions, aid in healing severe, infected wounds, suspect for biofilm formation. Therefore we presumed maggot excretions/secretions would reduce biofilm formation.

N-acetylcysteine Protects Striated Muscle in a Model of Compartment Syndrome

Stephen R. Kearns FRCS (Tr&Orth), David E. O’Briain IMRCS, Katherine M. Sheehan MD, Cathal Kelly FRCSI (Gen), David Bouchier-Hayes FRCSI

To avoid ischemic necrosis, compartment syndrome is a surgical emergency treated with decompression once identified. A potentially lethal, oxidant-driven reperfusion injury occurs after decompression. N-acetylcysteine is an antioxidant with the potential to attenuate the reperfusion injury.