Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Basic Research 173 articles


Evaluation of Two Sources of Calcium Sulfate for a Local Drug Delivery System: A Pilot Study

Ashley C. Parker BS, J. Keaton Smith MS, Harry S. Courtney PhD, Warren O. Haggard PhD

Local drug delivery has substantial potential to prevent infections compared with systemic delivery. Although calcium sulfate (CaSO) has been studied for local drug delivery and two types are commercially available, it is unknown whether they differentially release antibiotics.

Human Periosteum Is a Source of Cells for Orthopaedic Tissue Engineering: A Pilot Study

Michael D. Ball PhD, Ian C. Bonzani PhD, Melissa J. Bovis BSc, Andrew Williams MBBS, Molly M. Stevens PhD

Periosteal cells are important in embryogenesis, fracture healing, and cartilage repair and could provide cells for osteochondral tissue engineering.

Vascularized Bone Grafting in a Canine Carpal Avascular Necrosis Model

Wouter F. Willems MD, Gregory M. Alberton MD, Allen T. Bishop MD, Thomas Kremer MD

Limited experimental research has been performed on the treatment of avascular necrosis (AVN) by vascularized bone grafting.

Growth Factor Delivery Through Self-assembling Peptide Scaffolds

Rachel E. Miller PhD, Paul W. Kopesky PhD, Alan J. Grodzinsky ScD

The best strategy for delivering growth factors to cells for the purpose of cartilage tissue engineering remains an unmet challenge. Tethering biotinylated insulin-like growth factor-1 (bIGF-1) to the self-assembling peptide scaffold (RADA)effectively delivers bioactive bIGF-1 to cardiac tissue.

Temporal Variation in Fixation Stiffness Affects Healing by Differential Cartilage Formation in a Rat Osteotomy Model

Bettina M. Willie PhD, Robert Blakytny PhD, Melanie Glöckelmann DVM, Anita Ignatius DVM, Lutz Claes PhD

Dynamization involves a reduction in fixation construct stiffness during bone healing, allowing increased interfragmentary movement of the fracture through physiologic weightbearing and muscle contraction. Within some optimal range, interfragmentary movement stimulates healing, but this range likely varies across stages of bone healing.

Human Early Fracture Hematoma Is Characterized by Inflammation and Hypoxia

Paula Kolar MD, Timo Gaber PhD, Carsten Perka MD, Georg N. Duda PhD, Frank Buttgereit MD

An effective immune system, especially during the inflammatory phase, putatively influences the quality and likelihood of bone healing. If and how this is reflected within the initial fracture hematoma is unclear.

Relationships of the Lateral Femoral Cutaneous Nerve to Bony Landmarks

Mehmet Üzel MD, PhD, Salih Murat Akkin MD, Ercan Tanyeli MD, Jürgen Koebke PhD

The lateral femoral cutaneous nerve (LFCN) can be at risk during, for example, the insertion of pins in the anterior superior iliac spine (ASIS) during external fixation of the pelvis, total hip arthroplasty through a direct anterior approach, open surgery for impingement in the hip through an anterior approach, and periacetabular osteotomy. During surgery, the surgeon usually assumes the location of the LFCN by using the ASIS as a landmark.

Bupivacaine and Triamcinolone May Be Toxic To Human Chondrocytes: A Pilot Study

Hasan M. Syed MD, Lora Green PhD, Brandon Bianski BS, Christopher M. Jobe MD, Montri D. Wongworawat MD

Intraarticular injections of corticosteroids combined with local anesthetics are commonly used for management of chronic pain symptoms associated with degenerative joint diseases and after arthroscopic procedures. Several studies suggest chondrotoxicity of local anesthetics whereas others report chondroprotective and cytotoxic effects of corticosteroids on cartilage. Given the frequency of use of these agents, it is important to know whether they are in fact toxic.

Engineered Cartilage Maturation Regulates Cytokine Production and Interleukin-1β Response

Silvia Francioli PhD, Carola Cavallo PhD, Brunella Grigolo PhD, Ivan Martin PhD, Andrea Barbero PhD

Because the injured joint has an actively inflammatory environment, the survival and repair potential of cartilage grafts may be influenced by inflammatory processes. Understanding the interactions of those processes with the graft may lead to concepts for pharmacologic or surgical solutions allowing improved cartilage repair.

Cell-based Meniscal Tissue Engineering: A Case for Synoviocytes

Derek B. Fox DVM, PhD, Diplomate ACVS, Jennifer J. Warnock DVM, PhD, Diplomate ACVS

Avascular meniscal injuries are largely incapable of healing; the most common treatment remains partial meniscectomy despite the risk of subsequent osteoarthritis. Meniscal responses to injury are partially mediated through synovial activity and strategies have been investigated to encourage healing through stimulating or transplanting adjacent synovial lining. However, with their potential for chondrogenesis, synovial fibroblast-like stem cells hold promise for meniscal cartilage tissue engineering.