Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Basic Research 169 articles

Articles

Wear-Corrosion Synergism in a CoCrMo Hip Bearing Alloy Is Influenced by Proteins

Mathew T. Mathew MD, Joshua J. Jacobs MD, Markus A. Wimmer PhD

Although numerous in vitro studies report on the tribological performance of and, separately, on the corrosion properties of cobalt-based alloys in metal-on-metal (MoM) bearings, the few studies that take into account the synergistic interaction of wear and corrosion (tribocorrosion) have used canonical tribo-test methods. We therefore developed synergistic study using a test method that more closely simulates hip bearing conditions.

Acetabular Cup Design Influences Deformational Response in Total Hip Arthroplasty

John B. Meding MD, Scott R. Small MS, Mary E. Jones, Michael E. Berend MD, Merrill A. Ritter MD

Press-fit acetabular components are susceptible to deformation in an underreamed socket, with excessive deformation of metal-on-metal (MOM) components potentially leading to increased torsional friction and micromotion. Specifically, however, it remains unclear how cup diameter, design, and time from implantation affect shell deformation.

GNAS1 and PHD2 Short-interfering RNA Support Bone Regeneration in Vitro and in an in Vivo Sheep Model

Carmen N. Ríos BS, Roman J. Skoracki MD, Anshu B. Mathur PhD

Our ability to guide cells in biomaterials for in vivo bone repair is limited and requires novel strategies. Short-interfering RNA (siRNA) allows the regulation of multiple cellular pathways. Core binding factor alpha 1 (Cbfa1) and hypoxia-inducible factor 1 (HIF-1) pathways can be modulated to direct bone formation via siRNA against guanine nucleotide-binding protein alpha-stimulating activity polypeptide 1 (siGNAS1) and prolyl hydroxylase domain-containing protein 2 (siPHD2), respectively.

Immune and Inflammatory Pathways are Involved in Inherent Bone Marrow Ossification

Umut Atakan Gurkan PhD, Ryan Golden BS, Vipuil Kishore PhD, Catherine P. Riley MS, Jiri Adamec PhD, Ozan Akkus PhD

Bone marrow plays a key role in bone formation and healing. Although a subset of marrow explants ossifies in vitro without excipient osteoinductive factors, some explants do not undergo ossification. The disparity of outcome suggests a significant heterogeneity in marrow tissue in terms of its capacity to undergo osteogenesis.

VEGF Improves Skeletal Muscle Regeneration After Acute Trauma and Reconstruction of the Limb in a Rabbit Model

Soenke Percy Frey MD, Hendrik Jansen MD, Michael J. Raschke MD, Rainer H. Meffert MD, Sabine Ochman MD

Complicated tibial fractures with severe soft tissue trauma are challenging to treat. Frequently associated acute compartment syndrome can result in scarring of muscles with impaired function. Several studies have shown a relationship between angiogenesis and more effective muscle regeneration. Vascular endothelial growth factor (VEGF) is associated with angiogenesis but it is not clear whether it would restore muscle force, reduce scarring, and aid in muscle regeneration after acute musculoskeletal trauma.

Surgical Revascularization Induces Angiogenesis in Orthotopic Bone Allograft

Wouter F. Willems MD, Thomas Kremer MD, Patricia Friedrich AAS, Allen T. Bishop MD

Remodeling of structural bone allografts relies on adequate revascularization, which can theoretically be induced by surgical revascularization. We developed a new orthotopic animal model to determine the technical feasibility of axial arteriovenous bundle implantation and resultant angiogenesis.

Precision and Accuracy Measurement of Radiostereometric Analysis Applied to Movement of the Sacroiliac Joint

Thomas J. Kibsgård MD, Olav Røise MD, PhD, Britt Stuge PT, PhD, Stephan M. Röhrl MD, PhD

Different techniques have been used to quantify the movement of sacroiliac (SI) joints. These include radiostereometric analysis (RSA), but the accuracy and precision of this method have not been properly evaluated and it is unclear how many markers are required and where they should be placed to achieve proper accuracy and precision.

One-Screw Fixation Provides Similar Stability to That of Two-Screw Fixation for Type II Dens Fractures

Gang Feng MD, Robert Wendlandt Dipl-Ing, Sebastian Spuck MD, Arndt P. Schulz MD, PhD, MRCS

Anterior screw fixation has been widely adopted for the treatment of Type II dens fractures. However, there is still controversy regarding whether one- or two-screw fixation is more appropriate.

Cis-2-decenoic Acid Inhibits S. aureus Growth and Biofilm In Vitro: A Pilot Study

Jessica Amber Jennings PhD, Harry S. Courtney PhD, Warren O. Haggard PhD

Cis-2 decenoic acid (C2DA) disperses biofilm in many strains of microorganisms. However, whether C2DA inhibits bacterial growth or has potential to boost the actions of antibiotics is unknown.

Adult Stem Cell Mobilization Enhances Intramembranous Bone Regeneration: A Pilot Study

Margaret A. McNulty PhD, Amarjit S. Virdi PhD, Kent W. Christopherson PhD, Kotaro Sena DDS, PhD, Robin R. Frank BS, Dale R. Sumner PhD

Stem cell mobilization, which is defined as the forced egress of stem cells from the bone marrow to the peripheral blood (PB) using chemokine receptor agonists, is an emerging concept for enhancing tissue regeneration. However, the effect of stem cell mobilization by a single injection of the C-X-C chemokine receptor type 4 (CXCR4) antagonist AMD3100 on intramembranous bone regeneration is unclear.