Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Online First™

Articles

No Need to be Nervous About Microsuturing?

Benjamin K. Potter MD, FACS
18th May 2017, From Bench to Bedside

Complete Circumferential Osseous Extension in the Acetabular Rim Occurs Regardless of Acetabular Coverage

Keisuke Watarai MD, Fumihiko Kimura MD, Yuho Kadono MD, PhD, Yoon Taek Kim MD, PhD, Mamoru Niitsu MD, PhD, Hiromi Oda MD, PhD, Hirohiko Azuma MD, PhD
16th May 2017, Clinical Research

Complete circumferential osseous extension in the acetabular rim has been reported to occur in the deep hip with pincer impingement. However, this phenomenon occasionally is observed in dysplastic hips without pincer impingement, and the degree to which this finding might or might not be associated with hip pain, and how often it occurs bilaterally among patients, are not well characterized.

What Is the Mid-term Failure Rate of Revision ACL Reconstruction? A Systematic Review

Alberto Grassi MD, Christopher Kim MD, Giulio Maria Marcheggiani Muccioli MD, Stefano Zaffagnini MD, Annunziato Amendola MD
10th May 2017, Symposium: Improving Care for Patients With ACL Injuries: A Team Approach

When anterior cruciate ligament (ACL) reconstruction fails, a revision procedure may be performed to improve knee function, correct instability, and allow return to activities. The results of revision ACL reconstruction have been reported to produce good but inferior patient-reported and objective outcomes compared with primary ACL reconstruction, but the degree to which this is the case varies widely among published studies and may be influenced by heterogeneity of patients, techniques, and endpoints assessed. For those reasons, a systematic review may provide important insights.

Increase in Total Joint Arthroplasty Projected from 2014 to 2046 in Australia: A Conservative Local Model With International Implications

Maria C. S. Inacio PhD, Stephen E. Graves MBBS, DPhil, Nicole L. Pratt PhD, Elizabeth E. Roughead PhD, Szilard Nemes PhD
9th May 2017, Clinical Research

The incidence of joint arthroplasty is increasing worldwide. International estimates of future demand for joint arthroplasty have used models that propose either an exponential future increase, despite obvious system constraints, or static increases, which do not account for past trends. Country-specific projection estimates that address limitations of past projections are necessary. In Australia, a high-income country with the 7th highest incidence of TKA and 15th highest incidence of THA of the Organization for Economic Cooperation and Development (OECD) countries, the volume of TKAs and THAs increased 198% between 1994 and 2014.

High Interspecimen Variability in Engagement of the Anterolateral Ligament: An In Vitro Cadaveric Study

Robert N. Kent BSE, James F. Boorman-Padgett BS, Ran Thein MD, Jelle P. List MD, Danyal H. Nawabi MD, Thomas L. Wickiewicz MD, Carl W. Imhauser PhD, Andrew D. Pearle MD
5th May 2017, Symposium: Improving Care for Patients With ACL Injuries: A Team Approach

Anterolateral ligament (ALL) reconstruction as an adjunct to anterior cruciate ligament (ACL) reconstruction remains a subject of clinical debate. This uncertainty may be driven in part by a lack of knowledge regarding where, within the range of knee motion, the ALL begins to carry force (engages).

Free Vascularized Fibular Grafting Improves Vascularity Compared With Core Decompression in Femoral Head Osteonecrosis: A Randomized Clinical Trial

Lu Cao MD, Changan Guo MD, Jifei Chen MD, Zenggan Chen MD, Zuoqin Yan MD
4th May 2017, Clinical Research

Management of osteonecrosis of the femoral head remains challenging. Core decompression and free vascularized fibular grafting are commonly used surgical procedures for treatment of osteonecrosis of the femoral head. Few studies, however, have compared these two procedures in a randomized controlled study, in terms of improved vascularity of the femoral head, progression of disease, or hip scores.

Combined Administration of ASCs and BMP-12 Promotes an M2 Macrophage Phenotype and Enhances Tendon Healing

Richard H. Gelberman MD, Stephen W. Linderman MPhil, Rohith Jayaram MS, Anna D. Dikina PhD, Shelly Sakiyama-Elbert PhD, Eben Alsberg PhD, Stavros Thomopoulos PhD, Hua Shen PhD
1st May 2017, Basic Research

Outcomes after intrasynovial tendon repair are highly variable. An intense inflammatory cascade followed by a delayed healing response can cause adhesion formation and repair-site failure that severely impair the function of repaired digits. No effective remedies exist to fully address these issues. Cell- and growth factor-based therapies have been shown to modulate inflammation and improve cell proliferation and matrix synthesis and therefore are promising treatment approaches for intrasynovial tendon repair.

Knee Abduction Affects Greater Magnitude of Change in ACL and MCL Strains Than Matched Internal Tibial Rotation In Vitro

Nathaniel A. Bates PhD, Rebecca J. Nesbitt PhD, Jason T. Shearn PhD, Gregory D. Myer PhD, Timothy E. Hewett PhD
28th April 2017, Symposium: Improving Care for Patients With ACL Injuries: A Team Approach

Anterior cruciate ligament (ACL) injures incur over USD 2 billion in annual medical costs and prevention has become a topic of interest in biomechanics. However, literature conflicts persist over how knee rotations contribute to ACL strain and ligament injury. To maximize the efficacy of ACL injury prevention, the effects of underlying mechanics need to be better understood.

Prolotherapy Induces an Inflammatory Response in Human Tenocytes In Vitro

Emmanuel C. Ekwueme PhD, Mahir Mohiuddin BS, Jazmin A. Yarborough, P. Gunnar Brolinson DO, Denitsa Docheva PhD, Hugo A. M. Fernandes PhD, Joseph W. Freeman PhD
27th April 2017, Basic Research

Proliferative therapy, or prolotherapy, is a controversial treatment method for many connective tissue injuries and disorders. It involves the injection of a proliferant, or irritant solution, into the site of injury, which causes small-scale cell death. This therapeutic trauma is theorized to initiate the body’s wound-healing cascade, perhaps leading to tissue repair. The immediate effects of many of these proliferants are poorly characterized, as are the cellular responses to them; here, we sought to evaluate the immediate effects of two common proliferants (dextrose and P2G, a combination of phenol, glucose, and glycerin) on the cellular response of human tenocytes, and begin to explicate the mechanisms with which each proliferant functions.