Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Online First™

Articles

Knee Abduction Affects Greater Magnitude of Change in ACL and MCL Strains Than Matched Internal Tibial Rotation In Vitro

Nathaniel A. Bates PhD, Rebecca J. Nesbitt PhD, Jason T. Shearn PhD, Gregory D. Myer PhD, Timothy E. Hewett PhD
28th April 2017, Symposium: Improving Care for Patients With ACL Injuries: A Team Approach

Anterior cruciate ligament (ACL) injures incur over USD 2 billion in annual medical costs and prevention has become a topic of interest in biomechanics. However, literature conflicts persist over how knee rotations contribute to ACL strain and ligament injury. To maximize the efficacy of ACL injury prevention, the effects of underlying mechanics need to be better understood.

Prolotherapy Induces an Inflammatory Response in Human Tenocytes In Vitro

Emmanuel C. Ekwueme PhD, Mahir Mohiuddin BS, Jazmin A. Yarborough, P. Gunnar Brolinson DO, Denitsa Docheva PhD, Hugo A. M. Fernandes PhD, Joseph W. Freeman PhD
27th April 2017, Basic Research

Proliferative therapy, or prolotherapy, is a controversial treatment method for many connective tissue injuries and disorders. It involves the injection of a proliferant, or irritant solution, into the site of injury, which causes small-scale cell death. This therapeutic trauma is theorized to initiate the body’s wound-healing cascade, perhaps leading to tissue repair. The immediate effects of many of these proliferants are poorly characterized, as are the cellular responses to them; here, we sought to evaluate the immediate effects of two common proliferants (dextrose and P2G, a combination of phenol, glucose, and glycerin) on the cellular response of human tenocytes, and begin to explicate the mechanisms with which each proliferant functions.

Variations in Knee Kinematics After ACL Injury and After Reconstruction Are Correlated With Bone Shape Differences

Drew A. Lansdown MD, Valentina Pedoia PhD, Musa Zaid MD, Keiko Amano MD, Richard B. Souza PT, PhD, Xiaojuan Li PhD, C. Benjamin Ma MD
27th April 2017, Symposium: Improving Care for Patients With ACL Injuries: A Team Approach

The factors that contribute to the abnormal knee kinematics after anterior cruciate ligament (ACL) injury and ACL reconstruction remain unclear. Bone shape has been implicated in the development of hip and knee osteoarthritis, although there is little knowledge about the effects of bone shape on knee kinematics after ACL injury and after ACL reconstruction.

Editorial Comment: 2016 Musculoskeletal Infection Society Proceedings

Charalampos G. Zalavras MD, PhD, Bryan D. Springer MD
25th April 2017, Symposium: 2016 Musculoskeletal Infection Society Proceedings