Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Symposium:Clinically Relevant Strategies for Treating Cartilage and Meniscal Pathology 1 article


Coculture of Engineered Cartilage With Primary Chondrocytes Induces Expedited Growth

Andrea R. Tan MS, Elizabeth Y. Dong BS, James P. Andry MD, J. Chloƫ Bulinski PhD, Gerard A. Ateshian PhD, Clark T. Hung PhD

Soluble factors released from chondrocytes can both enhance and induce chondrocyte-like behavior in cocultured dedifferentiated cells. The ability to similarly prime and modulate biosynthetic activity of differentiated cells encapsulated in a three-dimensional environment is unknown.