Clinical Orthopaedics and Related Research ®

A Publication of The Association of Bone and Joint Surgeons ®

Symposium: Bone Repair and Regeneration 10 articles


Functional Restoration of Critically Sized Segmental Defects With Bone Morphogenetic Protein-2 and Heparin Treatment

Mela R. Johnson PhD, Joel D. Boerckel MS, Kenneth M. Dupont PhD, Robert E. Guldberg PhD

Bone defects and fracture nonunions remain a substantial challenge for clinicians. Grafting procedures are limited by insufficient volume and donor site morbidity. As an alternative, biomaterial scaffolds functionalized through incorporation of growth factors such as bone morphogenetic proteins (BMPs) have been developed and appear to regenerate the structure and function of damaged or degenerated skeletal tissue.

Influence of Gender and Fixation Stability on Bone Defect Healing in Middle-aged Rats: A Pilot Study

Manav Mehta PhD, Georg N. Duda PhD, Carsten Perka MD, Patrick Strube MD

Gender and stability of fixation independently influence bone regeneration but their combined effects are unclear.

Human Periosteum Is a Source of Cells for Orthopaedic Tissue Engineering: A Pilot Study

Michael D. Ball PhD, Ian C. Bonzani PhD, Melissa J. Bovis BSc, Andrew Williams MBBS, Molly M. Stevens PhD

Periosteal cells are important in embryogenesis, fracture healing, and cartilage repair and could provide cells for osteochondral tissue engineering.

How Much Vitamin D Do We Need for Skeletal Health?

Christoph Domarus MD, Jonathan Brown Dipl-Ing, Florian Barvencik MD, Michael Amling MD, Pia Pogoda MD

Vitamin D is critical for musculoskeletal health and has been implicated in the risk of extraskeletal diseases, including cancer, cardiovascular diseases, and autoimmune diseases, as well as overall mortality. Although numerous studies deal and have dealt with vitamin D deficiency and its consequences, experts cannot agree on the right 25-hydroxyvitamin D levels. This survey aims to shed light on the ongoing vitamin D controversy from different angles.

Temporal Variation in Fixation Stiffness Affects Healing by Differential Cartilage Formation in a Rat Osteotomy Model

Bettina M. Willie PhD, Robert Blakytny PhD, Melanie Glöckelmann DVM, Anita Ignatius DVM, Lutz Claes PhD

Dynamization involves a reduction in fixation construct stiffness during bone healing, allowing increased interfragmentary movement of the fracture through physiologic weightbearing and muscle contraction. Within some optimal range, interfragmentary movement stimulates healing, but this range likely varies across stages of bone healing.

Human Early Fracture Hematoma Is Characterized by Inflammation and Hypoxia

Paula Kolar MD, Timo Gaber PhD, Carsten Perka MD, Georg N. Duda PhD, Frank Buttgereit MD

An effective immune system, especially during the inflammatory phase, putatively influences the quality and likelihood of bone healing. If and how this is reflected within the initial fracture hematoma is unclear.